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马来西亚肥胖症的遗传变异：范围综述。

Genetic Variants of Obesity in Malaysia: A Scoping Review.

机构信息

Endocrine and Metabolic Unit, Nutrition, Metabolic & Cardiovascular Research Centre, Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Setia Alam 40170, Selangor, Malaysia.

出版信息

Genes (Basel). 2024 Oct 17;15(10):1334. doi: 10.3390/genes15101334.

DOI:10.3390/genes15101334
PMID:39457458
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11507395/
Abstract

BACKGROUND

Obesity is a pressing public health issue in Malaysia, involving not only excess weight but also complex metabolic and physiological changes. Addressing these complexities requires comprehensive strategies, including understanding the population-level differences in obesity susceptibility. This review aims to compile the genetic variants studied among Malaysians and emphasize their implications for obesity risk.

METHODS

Relevant articles published up to March 2024 were extracted from the Scopus, PubMed, and ScienceDirect databases. The review process was conducted in accordance with the PRISMA-ScR guidelines. From an initial pool of 579 articles, 35 of these were selected for the final review.

RESULTS

The identified gene variants, including (K656N), (G2548A-Indian only), (rs17366568), (45bp-I/D), (rs4994), (rs3827103), (pro12Ala-Malay only), (intron 2 VNTR), (rs28362491), and (rs174547-Indian only), showed significant associations with obesity as measured by the respective studies.

CONCLUSIONS

Overall, more intensive genetic research is needed, starting with population-based profiling of genetic data on obesity, including among children. Sociocultural contexts and environmental factors influence variations in genetic elements, highlighting the need for targeted interventions to mitigate the impacts of obesity in the population.

摘要

背景

肥胖是马来西亚一个紧迫的公共卫生问题，不仅涉及体重超标，还涉及复杂的代谢和生理变化。解决这些复杂性问题需要综合策略，包括了解肥胖易感性在人群水平上的差异。本综述旨在汇编在马来西亚人群中研究过的遗传变异，并强调它们对肥胖风险的影响。

方法

从 Scopus、PubMed 和 ScienceDirect 数据库中提取截至 2024 年 3 月发表的相关文章。综述过程遵循 PRISMA-ScR 指南进行。从最初的 579 篇文章中，选择了 35 篇进行最终综述。

结果

确定的基因变异包括 （K656N）、 （G2548A-仅印度）、 （rs17366568）、 （45bp-I/D）、 （rs4994）、 （rs3827103）、 （pro12Ala-仅马来人）、 （内含子 2 VNTR）、 （rs28362491）和 （rs174547-仅印度），这些变异与肥胖有关，肥胖的衡量标准是各自研究中的相关指标。

结论

总体而言，需要进行更深入的遗传研究，首先要对肥胖人群的遗传数据进行基于人群的分析，包括儿童人群。社会文化背景和环境因素影响遗传因素的变异，这强调了需要采取有针对性的干预措施来减轻肥胖对人群的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5a/11507395/341930c4e773/genes-15-01334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5a/11507395/3f2e62036cf5/genes-15-01334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5a/11507395/341930c4e773/genes-15-01334-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5a/11507395/3f2e62036cf5/genes-15-01334-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9e5a/11507395/341930c4e773/genes-15-01334-g002.jpg

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