马来西亚马来人中黑素皮质素-4受体基因多态性与肥胖相关参数的关联
Association of melanocortin-4 receptor gene polymorphisms with obesity-related parameters in Malaysian Malays.
作者信息
Apalasamy Yamunah Devi, Ming Moy Foong, Rampal Sanjay, Bulgiba Awang, Mohamed Zahurin
机构信息
Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
出版信息
Ann Hum Biol. 2013 Jan;40(1):102-6. doi: 10.3109/03014460.2012.720709. Epub 2012 Sep 18.
BACKGROUND
Melanocortin-4 receptor (MC4R) is an important regulator of body weight and energy intake. Genetic polymorphisms of the MC4R gene have been found to be linked to obesity in many recent studies across the globe.
AIM
This study aimed to examine the effects of MC4R polymorphisms on obesity parameters, Linkage disequilibrium (LD) pattern and haplotypes in Malaysian Malays.
METHODS
The study subjects were 652 Malaysian Malays. Genomic DNA was extracted from buccal swabs. Genotyping was performed using Sequenom MassARRAY® iPLEX platform. Anthropometric and blood lipid profiles were measured.
RESULTS
MC4R rs571312 SNP was associated with logBMI (p = 0.008) and systolic blood pressure (p = 0.005), while MC4R rs2229616 SNP was associated with total cholesterol (TC) levels (p = 0.016). The MC4R rs7227255 SNP did not show any association with obesity parameters.
CONCLUSIONS
The strength of LD of the MC4R gene region is low and the haplotypes were not associated with obesity in Malaysian Malays.
背景
黑皮质素-4受体（MC4R）是体重和能量摄入的重要调节因子。全球许多近期研究发现，MC4R基因的遗传多态性与肥胖有关。
目的
本研究旨在探讨MC4R基因多态性对马来西亚马来人肥胖参数、连锁不平衡（LD）模式和单倍型的影响。
方法
研究对象为652名马来西亚马来人。从口腔拭子中提取基因组DNA。使用Sequenom MassARRAY® iPLEX平台进行基因分型。测量人体测量学和血脂谱。
结果
MC4R rs571312 SNP与logBMI（p = 0.008）和收缩压（p = 0.005）相关，而MC4R rs2229616 SNP与总胆固醇（TC）水平相关（p = 0.016）。MC4R rs7227255 SNP与肥胖参数无任何关联。
结论
MC4R基因区域的LD强度较低，单倍型与马来西亚马来人的肥胖无关。
Zotero 插件