Gismondo M R, Lo Bue A M, Chisari G
Istituto di Microbiologia, Università degli Studi di Catania.
G Chir. 1990 Jul-Aug;11(7-8):439-42.
The authors have carried out an experimental study to evaluate the interference of sub-inhibitory concentrations of clindamycin on the adherence of slime producing S. epidermidis to surgical nets and its ability to infect rabbits. 80 rabbits divided into 4 groups, (A, B, C, and D), underwent sham operation of the abdominal zone and were sewn up with sterile nets, infected nets and sub MIC of clindamycin equal to 1/8 MIC, respectively. The results obtained stressed a different survival rate 12 days after operation: 95% in group A, 35% in group B; 100% in group C and 95% in group D. This data were confirmed by the results obtained using MES (Cambridge Stereosecan 150 KM2). From our research an excellent clindamycin inhibitory activity on the pathogenicity of slime producing staphylococci emerged.
作者开展了一项实验研究，以评估亚抑菌浓度的克林霉素对产黏液表皮葡萄球菌黏附手术网片的干扰作用及其感染家兔的能力。80只家兔分为4组（A、B、C和D组），接受腹部区域的假手术，分别用无菌网片、感染网片和等于1/8 MIC的克林霉素亚抑菌浓度进行缝合。术后12天获得的结果显示出不同的存活率：A组为95%，B组为35%；C组为100%，D组为95%。使用MES（剑桥立体扫描150 KM2）获得的结果证实了这些数据。从我们的研究中可以看出，克林霉素对产黏液葡萄球菌的致病性具有出色的抑制活性。
