Institute for Bioinformatics and Systems Biology, Helmholtz Zentrum München - German Research Center for Environmental Health (GmbH), Ingolstädter Landstraße 1, D-85764, Neuherberg, Germany +49 89 3187 2788 ; +49 89 3187 3585 ;
Expert Opin Drug Discov. 2010 Apr;5(4):323-31. doi: 10.1517/17460441003716796.
In recent years, proteomics has become a common technique applied to a wide spectrum of scientific problems, including the identification of diagnostic biomarkers, monitoring the effects of drug treatments or identification of chemical properties of a protein or a drug. Although being significantly different in scientific essence, the ultimate result of the majority of proteomics studies is a protein list. Thousands of independent proteomics studies have reported protein lists in various functional contexts.
We review here the spectrum of scientific problems where proteomics technology was applied recently to deliver protein lists. The available bioinformatics methods commonly used to understand the properties of the protein lists are compared.
The types and common functional properties of the reported protein lists are discussed. The range of scientific problems where this knowledge could be potentially helpful with a focus on drug discovery issues is explored.
Reported protein lists represent a valuable resource which can be used for a variety of goals, ranging from biomarkers discovery to identification of novel therapeutic implications of known drugs.
近年来，蛋白质组学已成为一种常见的技术，应用于广泛的科学问题，包括诊断生物标志物的鉴定、药物治疗效果的监测或蛋白质或药物的化学性质的鉴定。尽管在科学本质上有很大的不同，但大多数蛋白质组学研究的最终结果是一个蛋白质列表。数千项独立的蛋白质组学研究在各种功能背景下报告了蛋白质列表。
我们在这里回顾了近年来应用蛋白质组学技术提供蛋白质列表的一系列科学问题。比较了常用的可用于了解蛋白质列表性质的生物信息学方法。
讨论了报告的蛋白质列表的类型和常见的功能特性。探讨了该知识在各种科学问题中可能具有的潜在帮助范围，重点是药物发现问题。
报告的蛋白质列表是一种有价值的资源，可用于多种目的，从生物标志物的发现到鉴定已知药物的新治疗意义。
