Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India.
Indian J Ophthalmol. 2012 Jul;60(4):311-3. doi: 10.4103/0301-4738.98712.
The outcome of four cases of sterile endophthalmitis that developed after intravitreal injections of bevacizumab has been reported here. All four eyes received 1.25 mg/0.05 ml intravitreal bevacizumab from 0.2-ml aliquots for different etiologies. The inflammation predominantly involved the anterior chamber with mild vitreous reaction. All patients were culture negative and regained preinjection visual acuity and were culture negative following intravitreal antibiotic administration. This report highlights that intravitreal bevacizumab can cause sterile endophthalmitis and this has to be kept in mind, and clinical judgment should be used to differentiate it from infective endophthalmitis.
这里报告了 4 例在玻璃体内注射贝伐单抗后发生无菌性眼内炎的病例。这 4 只眼睛均因不同病因从 0.2ml 等分液中接受了 1.25mg/0.05ml 的玻璃体内贝伐单抗注射。炎症主要累及前房，玻璃体反应轻微。所有患者均为培养阴性，在玻璃体内应用抗生素后视力恢复到注射前水平，且培养结果为阴性。本报告强调，玻璃体内注射贝伐单抗可引起无菌性眼内炎，这一点必须牢记，并且应该运用临床判断将其与感染性眼内炎区分开来。
