Geropsychiatry Section (116A), James A. Haley VA Hospital, University of South Florida College of Medicine, 13000 Bruce B. Downs BLVD, Tampa, FL 33612, USA.
J Anesth. 2012 Dec;26(6):925-7. doi: 10.1007/s00540-012-1455-x. Epub 2012 Jul 24.
There is increasing evidence that a greater degree of postictal suppression (the abruptness and magnitude of the EEG voltage drop at the end of the seizure) may be associated with better clinical response to electroconvulsive therapy. Retrospective studies have shown better postictal suppression when propofol is used for induction rather than the more commonly used methohexital. We report two patients in whom poor postictal suppression was rectified by switching from methohexital to propofol. The clinical significance of this improvement in postictal suppression is unclear, and prospective studies will be needed to clarify any clinical benefits.
越来越多的证据表明，更大程度的发作后抑制（癫痫发作结束时 EEG 电压下降的突然性和幅度）可能与电惊厥治疗的更好临床反应相关。回顾性研究表明，与更常用的甲己炔巴比妥钠相比，使用异丙酚诱导时发作后抑制更好。我们报告了两例患者，他们将甲己炔巴比妥钠切换为异丙酚后，发作后抑制不良得到纠正。这种发作后抑制改善的临床意义尚不清楚，需要前瞻性研究来阐明任何临床益处。
