Suppes T, Webb A, Carmody T, Gordon E, Gutierrez-Esteinou R, Hudson J I, Pope H G
University of Texas Southwestern Medical Center at Dallas, USA.
J Affect Disord. 1996 Nov 4;41(1):55-8. doi: 10.1016/0165-0327(96)00066-3.
Electroconvulsive therapy (ECT) is an established effective treatment modality for patients with severe depression. Recent studies have focused on developing predictors of response. In this prospective study, using percent decrease in Hamilton Depression Scale (21 items) as the outcome measure, we blindly evaluated 33 inpatients with major depression to determine whether postictal suppression, the electrical silence following induced seizure, would predict treatment response to ECT. A significant relationship was observed between degree of postictal suppression and likelihood of clinical improvement. Postictal suppression should be explored in more controlled studies as a predictor of ECT response.
电休克疗法（ECT）是治疗重度抑郁症患者的一种行之有效的既定治疗方式。近期研究聚焦于开发疗效预测指标。在这项前瞻性研究中，我们以汉密尔顿抑郁量表（21项）得分的下降百分比作为疗效指标，对33例重度抑郁症住院患者进行了盲法评估，以确定发作后抑制（即诱发癫痫发作后的电静息状态）是否能预测ECT治疗反应。结果发现，发作后抑制程度与临床改善可能性之间存在显著关联。应在更多对照研究中探索发作后抑制作为ECT反应预测指标的作用。
