School of Engineering, University of Borås, SE-501 90 Borås, Sweden.
Physiol Meas. 2012 Aug;33(8):1363-77. doi: 10.1088/0967-3334/33/8/1363. Epub 2012 Jul 25.
Hypothermia has been proven as an effective rescue therapy for infants with moderate or severe neonatal hypoxic ischemic encephalopathy. Hypoxia-ischemia alters the electrical impedance characteristics of the brain in neonates; therefore, spectroscopic analysis of the cerebral bioimpedance of the neonate may be useful for the detection of candidate neonates eligible for hypothermia treatment. Currently, in addition to the lack of reference bioimpedance data obtained from healthy neonates, there is no standardized approach established for bioimpedance spectroscopy data analysis. In this work, cerebral bioimpedance measurements (12 h postpartum) in a cross-section of 84 term and near-term healthy neonates were performed at the bedside in the post-natal ward. To characterize the impedance spectra, Cole parameters (R(0), R(∞), f(C) and α) were extracted from the obtained measurements using an analysis process based on a best measurement and highest likelihood selection process. The results obtained in this study complement previously reported work and provide a standardized criterion-based method for data analysis. The availability of electrical bioimpedance spectroscopy reference data and the automatic criterion-based analysis method might support the development of a non-invasive method for prompt selection of neonates eligible for cerebral hypothermic rescue therapy.
低温疗法已被证明是治疗中重度新生儿缺氧缺血性脑病的有效抢救治疗方法。缺氧缺血改变了新生儿大脑的电阻抗特性；因此，对新生儿脑生物阻抗谱进行光谱分析，可能有助于发现适合低温治疗的候选新生儿。目前，除了缺乏从健康新生儿获得的参考生物阻抗数据外，生物阻抗光谱数据分析也没有建立标准化的方法。在这项工作中，在产后病房床边对 84 名足月和近足月健康新生儿进行了脑生物阻抗测量（产后 12 小时）。为了描述阻抗谱，使用基于最佳测量和最大似然选择过程的分析过程，从获得的测量值中提取 Cole 参数（R(0)、R(∞)、f(C)和α）。本研究的结果补充了以前的报告工作，并提供了一种基于标准的自动数据分析方法。电生物阻抗光谱参考数据的可用性和基于自动标准的分析方法可能支持开发一种用于快速选择适合脑低温抢救治疗的新生儿的非侵入性方法。
