Faculty of Public Health Services, Ostfalia - University of Applied Services, Wolfsburg, Germany.
Health Econ Rev. 2011 Jul 20;1(1):7. doi: 10.1186/2191-1991-1-7.
To compare improvement in quality of life (QoL) and symptoms' relief in vertebral compression fractures (VCF) due to osteoporosis for patients undergoing balloon kyphoplasty (BKP) to those undergoing non-surgical management (NSM) in a real-life setting.
In this prospective, comparative study, quality-of-life was evaluated in eight centres in Germany between 2005 and 2008, for 82 patients, with the EQ-5D questionnaire, and the Roland Morris Disability Questionnaire (RMDQ).
BKP patients demonstrated a statistical and clinical significant higher improvement in EQ-5D than NSM patients, 0.44 and 0.25 from baseline to 12 months, respectively. Moreover, BKP patients showed a clinically relevant improvement in the RMDQ by 6.25 from baseline to 12 months, whereas NSM patients had no significant improvement in the RMDQ.
This study demonstrates for VCF patients that in real-life quality of life for BKP patients improves more than for NSM patients; confirming the results of a large randomized clinical trial.
比较球囊扩张椎体后凸成形术（BKP）与非手术治疗（NSM）在真实环境下对骨质疏松性椎体压缩性骨折（VCF）患者生活质量（QoL）改善和症状缓解的效果。
在这项前瞻性、对照研究中，2005 年至 2008 年间，德国的 8 个中心使用 EQ-5D 问卷和 Roland Morris 残疾问卷（RMDQ）评估了 82 例患者的生活质量。
BKP 患者的 EQ-5D 评分从基线到 12 个月的改善明显高于 NSM 患者，分别为 0.44 和 0.25。此外，BKP 患者的 RMDQ 评分从基线到 12 个月有 6.25 的临床相关改善，而 NSM 患者的 RMDQ 评分没有显著改善。
本研究表明，对于 VCF 患者，BKP 患者的生活质量改善程度明显高于 NSM 患者，证实了一项大型随机临床试验的结果。
