吸烟影响应以包年衡量：误区 4。
That the effects of smoking should be measured in pack-years: misconceptions 4.
出版信息
Br J Cancer. 2012 Jul 24;107(3):406-7. doi: 10.1038/bjc.2012.97.
Abstract
Lung cancer incidence in smokers is roughly proportional to dose rate (cigarettes per day) but increases much more rapidly with duration of smoking. The assumption that the incidence rate is proportional to total lifetime dose (the product of dose rate and duration) has been known to be wrong for many years, but total dose in pack-years is still often included, either alone or together, with more fundamental parameters such as dose rate, in regression analysis of epidemiological data. This is mathematically unnecessary and scientifically unhelpful.
摘要
吸烟者的肺癌发病率与剂量率（每天吸烟的支数）大致成正比，但随着吸烟时间的延长，发病率增加得更快。多年来，人们已经知道，发病率与终生总剂量（剂量率与吸烟时间的乘积）成正比的假设是错误的，但在对流行病学数据进行回归分析时，仍经常单独或与更基本的参数（如剂量率）一起使用以年包数表示的总剂量。这在数学上是不必要的，在科学上也没有帮助。
相似文献
1
That the effects of smoking should be measured in pack-years: misconceptions 4.吸烟影响应以包年衡量：误区 4。
Br J Cancer. 2012 Jul 24;107(3):406-7. doi: 10.1038/bjc.2012.97.
2
Cigarette smoking and lung cancer: modeling total exposure and intensity.吸烟与肺癌：对总暴露量和强度进行建模
Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):517-23. doi: 10.1158/1055-9965.EPI-05-0863.
3
Cigarette smoking and lung cancer: modeling effect modification of total exposure and intensity.吸烟与肺癌：总暴露量和强度的效应修正建模
Epidemiology. 2007 Sep;18(5):639-48. doi: 10.1097/EDE.0b013e31812717fe.
4
Calculated cancer risks for conventional and "potentially reduced exposure product" cigarettes.传统香烟和“潜在低暴露量产品”香烟的计算癌症风险。
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):584-92. doi: 10.1158/1055-9965.EPI-06-0762.
5
Declining FEV1 and chronic productive cough in cigarette smokers: a 25-year prospective study of lung cancer incidence in Tecumseh, Michigan.吸烟者的第一秒用力呼气量下降和慢性咳痰：对密歇根州蒂卡姆西肺癌发病率的25年前瞻性研究。
Cancer Epidemiol Biomarkers Prev. 1994 Jun;3(4):289-98.
6
Risk factors for lung cancer in Iowa women: implications for prevention.爱荷华州女性肺癌的风险因素：对预防的启示。
Cancer Detect Prev. 2006;30(2):158-67. doi: 10.1016/j.cdp.2006.03.001. Epub 2006 Apr 3.
7
Lung cancer hormesis in high impact states where nuclear testing occurred.在进行过核试验的高影响地区的肺癌兴奋效应。
Clin Lung Cancer. 2015 Mar;16(2):152-5. doi: 10.1016/j.cllc.2014.09.010. Epub 2014 Oct 13.
8
Small cell lung cancer in women: risk associated with smoking, prior respiratory disease, and occupation.女性小细胞肺癌：与吸烟、既往呼吸系统疾病及职业相关的风险
Lung Cancer. 2000 Apr;28(1):1-10. doi: 10.1016/s0169-5002(99)00106-3.
9
Misunderstandings in the misconception on the use of pack-years in analysis of smoking.在吸烟分析中使用吸烟包年数时误解中的误解。
Br J Cancer. 2013 Mar 19;108(5):1218-20. doi: 10.1038/bjc.2013.76. Epub 2013 Feb 28.
10
Reply: misunderstandings in the misconception on the use of pack-years in analysis of smoking.回复：关于吸烟分析中使用吸烟包年数的误解中的误解。
Br J Cancer. 2013 Mar 19;108(5):1221. doi: 10.1038/bjc.2013.77. Epub 2013 Feb 28.
引用本文的文献
1
Effects of alcohol consumption from early adolescence on lung function and development of COPD - a retrospective cohort study.青春期早期饮酒对肺功能及慢性阻塞性肺疾病发展的影响——一项回顾性队列研究
Eur Clin Respir J. 2025 Mar 19;12(1):2476232. doi: 10.1080/20018525.2025.2476232. eCollection 2025.
2
Unrealistic risk perceptions of Iranian current cigarette smokers on developing lung cancer and chronic obstructive pulmonary disease (COPD): a cross-sectional study.伊朗当前吸烟者对患肺癌和慢性阻塞性肺疾病（COPD）风险的不切实际认知：一项横断面研究。
Sci Rep. 2024 Oct 27;14(1):25667. doi: 10.1038/s41598-024-77323-8.
3
Investigating the Obesity Paradox in Colorectal Cancer: An Analysis of Prospectively Collected Data in a Diverse Cohort.探究结直肠癌中的肥胖悖论：对不同队列中前瞻性收集数据的分析
Cancers (Basel). 2024 Aug 24;16(17):2950. doi: 10.3390/cancers16172950.
4
Associations between chronic obstructive pulmonary disease and ten common cancers: novel insights from Mendelian randomization analyses.慢性阻塞性肺疾病与十种常见癌症的关联：孟德尔随机分析的新见解。
BMC Cancer. 2024 May 17;24(1):601. doi: 10.1186/s12885-024-12381-9.
5
Pack-Year Smoking History: An Inadequate and Biased Measure to Determine Lung Cancer Screening Eligibility.吸烟包年数：一种评估肺癌筛查资格的不充分且有偏差的方法。
J Clin Oncol. 2024 Jun 10;42(17):2026-2037. doi: 10.1200/JCO.23.01780. Epub 2024 Mar 27.
6
Venous bicarbonate and CKD progression: a longitudinal analysis by the group-based trajectory model.静脉血碳酸氢盐与慢性肾脏病进展：基于群组轨迹模型的纵向分析
Clin Kidney J. 2023 Sep 1;16(11):1986-1992. doi: 10.1093/ckj/sfad207. eCollection 2023 Nov.
7
Non-small cell lung carcinoma (NSCLC): Implications on molecular pathology and advances in early diagnostics and therapeutics.非小细胞肺癌（NSCLC）：对分子病理学的影响以及早期诊断和治疗的进展
Genes Dis. 2022 Aug 23;10(3):960-989. doi: 10.1016/j.gendis.2022.07.023. eCollection 2023 May.
8
Cigarette Smoking, and Blood Monocyte Count Correlate with Chronic Lung Injuries and Mortality.吸烟和血单核细胞计数与慢性肺损伤和死亡率相关。
Int J Chron Obstruct Pulmon Dis. 2023 Apr 1;18:431-446. doi: 10.2147/COPD.S397667. eCollection 2023.
9
Dual inhibition of EGFR‑VEGF: An effective approach to the treatment of advanced non‑small cell lung cancer with EGFR mutation (Review).双重抑制 EGFR-VEGF：治疗 EGFR 突变的晚期非小细胞肺癌的有效方法（综述）。
Int J Oncol. 2023 Feb;62(2). doi: 10.3892/ijo.2023.5474. Epub 2023 Jan 5.
10
Association of smoking status, duration and amount with the risk of head and neck cancer subtypes: a national population-based study.吸烟状况、持续时间和吸烟量与头颈癌亚型风险的关联：一项基于全国人口的研究。
Am J Cancer Res. 2022 Oct 15;12(10):4815-4824. eCollection 2022.
本文引用的文献
1
That lung cancer incidence falls in ex-smokers: misconceptions 2.肺癌发病率在戒烟者中下降：误区 2。
Br J Cancer. 2011 Feb 1;104(3):389. doi: 10.1038/sj.bjc.6606080.
2
A small-cell lung cancer genome with complex signatures of tobacco exposure.具有复杂烟草暴露特征的小细胞肺癌基因组。
Nature. 2010 Jan 14;463(7278):184-90. doi: 10.1038/nature08629. Epub 2009 Dec 16.
3
Cigarette smoking and lung cancer: modeling effect modification of total exposure and intensity.吸烟与肺癌：总暴露量和强度的效应修正建模
Epidemiology. 2007 Sep;18(5):639-48. doi: 10.1097/EDE.0b013e31812717fe.
4
Cigarette smoking and lung cancer: reanalysis of the British doctors' data.吸烟与肺癌：对英国医生数据的重新分析
J Natl Cancer Inst. 1989 Mar 15;81(6):415-20. doi: 10.1093/jnci/81.6.415.
5
Radiation and exposure rate.辐射与照射率。
Nature. 1990 Apr 26;344(6269):824. doi: 10.1038/344824a0.
6
An epidemiological perspective of the biology of cancer.癌症生物学的流行病学视角。
Cancer Res. 1978 Nov;38(11 Pt 1):3573-83.
Zotero 插件