Xu N, Zhang G Z, Chen S H
Dept. of Hematologia, Zhong Shan Hospital, Shanghai Medical University.
Zhonghua Nei Ke Za Zhi. 1990 Jul;29(7):406-9, 444.
The effect of EPA enriched marine oil on platelet function in 12 cases of hypertension, 15 cases of diabetes and 20 cases of coronary heart disease is reported. The result of our study showed that there was platelet hyperfunction of various degrees in patients with those three kinds of diseases. The murine oil had an effect of inhibition, which were manifested by the prolongation on bleeding time, and decreased on platelet adhesion and aggregation. TxB2 in plasma was reduced, while 6-keto-PGF increased. There was no influence of EPA enriched fish oil on blood sugar and liver or kidney function. The authors concluded that platelet hyperfunction is an important element in the development of cardio vascular and cerebro vascular complications and increases the mortality rates in these diseases. Treatment with such a drug has beneficial effect with clinical improvement.
报告了富含二十碳五烯酸（EPA）的海洋油对12例高血压患者、15例糖尿病患者和20例冠心病患者血小板功能的影响。我们的研究结果表明，这三种疾病患者均存在不同程度的血小板功能亢进。鼠油具有抑制作用，表现为出血时间延长，血小板黏附和聚集减少。血浆中血栓素B2（TxB2）降低，而6-酮-前列腺素F1α（6-keto-PGF）升高。富含EPA的鱼油对血糖及肝肾功能无影响。作者得出结论，血小板功能亢进是心血管和脑血管并发症发生发展的重要因素，并增加了这些疾病的死亡率。使用此类药物治疗具有有益效果，可改善临床症状。
