东西伯利亚蜱传脑炎病毒：全基因组特征。

Tick-borne encephalitis virus in Eastern Siberia: complete genome characteristics.

机构信息

Laboratory of Analytical and Bioorganic Chemistry, Limnological Institute of SB RAS, 3, Ulan-Batorskaya Str, Irkutsk 664033, Russia.

出版信息

Arch Virol. 2012 Nov;157(11):2253-5. doi: 10.1007/s00705-012-1412-x. Epub 2012 Jul 25.

DOI:10.1007/s00705-012-1412-x

PMID:22828779

Abstract

Tick-borne encephalitis (TBE) is one of the most important arboviral diseases across Eurasia. TBE virus (TBEV) is transmitted by tick bite and causes a potentially fatal neurological infection in humans. In the Russian Federation, TBE is endemic in most regions, with 3000-5000 cases of the disease annually. To characterise TBEV in Eastern Siberia, the complete genomes of five TBEV isolates from patients with different clinical manifestations were sequenced. The results show that the Siberian and Far Eastern subtypes of TBEV cause the disease in people in Eastern Siberia. Complete genome analysis revealed an unexpectedly high genetic variability within the Siberian subtype.

摘要

蜱传脑炎（TBE）是欧亚大陆最重要的虫媒病毒病之一。蜱传脑炎病毒（TBEV）通过蜱叮咬传播，可导致人类潜在致命的神经系统感染。在俄罗斯联邦，TBE 在大多数地区流行，每年有 3000-5000 例病例。为了描述东西伯利亚的 TBEV，对来自不同临床表现患者的 5 株 TBEV 分离株的完整基因组进行了测序。结果表明，西伯利亚和远东亚型 TBEV 可导致东西伯利亚地区的人们患病。完整基因组分析显示，西伯利亚亚型内存在出乎意料的高遗传变异性。