Infection Biology Research Program, Department of Virology, Haartman Institute, FI-00014 University of Helsinki, Finland.
J Gen Virol. 2010 Nov;91(Pt 11):2706-12. doi: 10.1099/vir.0.023663-0. Epub 2010 Jul 21.
Tick-borne encephalitis (TBE) is a central nervous system infection caused by a flavivirus [tick-borne encephalitis virus (TBEV)], transmitted by Ixodes ticks and endemic in a large region in Eurasia. We collected 2411 ticks from Finland and Russia in 2003-2008, screened them for TBEV by RT-PCR and isolated and analysed eight strains belonging to all three TBEV subtypes; in addition, we obtained two European-subtype strains from human serum samples. TBEV RNA prevalence in unengorged ticks was approximately 1 % both in the northernmost TBE-endemic areas of Europe in Finland and Russian Karelia, and in Siberia in Buryatia. In Finland, both Ixodes ricinus and Ixodes persulcatus ticks were found from distinct areas and, in Russian Karelia, were overlapping in the same study site. TBEV E and NS3 gene sequences obtained showed a variability of 0-4 % within European-subtype strains, 2-9 % for Siberian-subtype strains and 3-13 % for Far Eastern-subtype strains.
蜱传脑炎（TBE）是一种由黄病毒[蜱传脑炎病毒（TBEV）]引起的中枢神经系统感染，通过硬蜱传播，在欧亚大陆的一个大区域流行。我们于 2003-2008 年在芬兰和俄罗斯收集了 2411 只蜱，通过 RT-PCR 对它们进行了 TBEV 筛查，并分离和分析了属于所有三种 TBEV 亚型的 8 株病毒；此外，我们还从人血清样本中获得了两株欧洲亚型毒株。在欧洲 TBE 流行地区最北部的芬兰和俄罗斯卡累利阿以及西伯利亚的布里亚特，未吸血的蜱中 TBEV RNA 的流行率约为 1%。在芬兰，发现了来自不同地区的 Ixodes ricinus 和 Ixodes persulcatus 蜱，而在俄罗斯卡累利阿，同一研究地点则存在重叠。获得的 TBEV E 和 NS3 基因序列显示，欧洲亚型毒株的变异率为 0-4%，西伯利亚亚型毒株为 2-9%，远东亚型毒株为 3-13%。
