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细胞周期S期p53肿瘤抑制基因的转录调控及细胞对DNA损伤的反应

Transcriptional Regulation of the p53 Tumor Suppressor Gene in S-Phase of the Cell-Cycle and the Cellular Response to DNA Damage.

作者信息

Reisman David, Takahashi Paula, Polson Amanda, Boggs Kristy

机构信息

Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA.

出版信息

Biochem Res Int. 2012;2012:808934. doi: 10.1155/2012/808934. Epub 2012 Jul 11.

DOI:10.1155/2012/808934
PMID:22830025
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3400299/
Abstract

The p53 tumor suppressor induces the transcription of genes that negatively regulate progression of the cell cycle in response to DNA damage or other cellular stressors and thus participates in maintaining genome stability. Numerous studies have demonstrated that p53 transcription is activated before or during early S-phase in cells progressing from G(0)/G(1) into S-phase through the combined action of two DNA-binding factors RBP-Jκ and C/EBPβ-2. Here, we review evidence that this induction occurs to provide available p53 mRNA in order to prepare the cell for DNA damage in S-phase, this ensuring a rapid response to DNA damage before exiting this stage of the cell cycle.

摘要

p53肿瘤抑制因子可诱导基因转录，这些基因会对DNA损伤或其他细胞应激源做出反应，负向调节细胞周期进程，从而参与维持基因组稳定性。大量研究表明，在细胞从G(0)/G(1)期进入S期的过程中，通过两种DNA结合因子RBP-Jκ和C/EBPβ-2的联合作用，p53转录在S期早期之前或期间被激活。在此，我们综述相关证据，即这种诱导作用的发生是为了提供可用的p53 mRNA，以便细胞为S期的DNA损伤做好准备，从而确保在退出细胞周期的这一阶段之前对DNA损伤做出快速反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4f9/3400299/7f257ae3774f/BCRI2012-808934.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4f9/3400299/7f257ae3774f/BCRI2012-808934.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d4f9/3400299/7f257ae3774f/BCRI2012-808934.001.jpg

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