Amin Adnan, Khan Muhammad Ayaz, Azam Sheikh Muhammad Farooq, Haroon Uzma
Gomal Centre of Biochemistry and Biotechnology, Gomal University, DI Khan, Pakistan.
J Ayub Med Coll Abbottabad. 2011 Jan-Mar;23(1):19-22.
The rational drug prescribing practice is an important health concern around the globe that not only interferes patient's life but also the socioeconomic issues.
The aim of current study was to evaluate the rational use of drug, prescribing behaviour of consultant physicians, role of medical team members in irrational therapy and form the basis for providing necessary information to the policy makers.
This cross-sectional study was conducted involving a set of 340 medication orders containing about 1,755 medications prescribed to patients in DHQ Teaching Hospital DI Khan, Pakistan from March to July 2009. The WHO operational package for monitoring and assessing country pharmaceutical situations indicators were used for data collection.
Among drugs prescribed per average encounter, 75% were dispensed from hospital pharmacy. Generally about 22.3% encounters of overdosing, 16.16% drug duplication, 24.25% drug-drug interactions, 3.5% adverse drug effects and 3.8% cases of contraindications were recorded. The proportion of consultations with antibiotics and injectables prescribed was 80% and 57% respectively. Likewise not less than 70% patients were prescribed NSAIDS, 67% steroids, 55% vitamin supplements, and 34% oral re-hydration solutions. Minimum 5 drugs per prescription were recorded and 70% of prescriptions were reported with high cost of therapy.
The drug practice among hospitalised patients was clearly irrational accompanied by high levels of medication error. An accurate prescribing decision, appropriate treatment, and rational use of drugs are major needs of the day to ensure safe medication practice.
合理用药是全球重要的健康问题，不仅会影响患者生活，还会涉及社会经济问题。
本研究旨在评估药物的合理使用情况、会诊医师的处方行为、医疗团队成员在不合理治疗中的作用，并为政策制定者提供必要信息奠定基础。
本横断面研究涉及2009年3月至7月在巴基斯坦迪坎DHQ教学医院开具的340组包含约1755种药物的医嘱。采用世界卫生组织用于监测和评估国家药品状况指标的操作包进行数据收集。
在每次平均会诊开具的药物中，75%是从医院药房调配的。总体上，记录到约22.3%的会诊存在用药过量、16.16%的药物重复、24.25%的药物相互作用、3.5%的药物不良反应以及3.8%的禁忌证病例。开具抗生素和注射剂的会诊比例分别为80%和57%。同样，不少于70%的患者开具了非甾体抗炎药、67%的患者开具了类固醇、55%的患者开具了维生素补充剂，以及34%的患者开具了口服补液溶液。每张处方至少记录了5种药物，70%的处方报告治疗费用高昂。
住院患者的用药行为明显不合理，用药错误率较高。准确的处方决策、恰当的治疗以及合理用药是当今确保安全用药实践的主要需求。
