Bilal Mohammad, Tariq Areej, Khan Somal, Tariq Ayesha, Shahid Muhammad Farooq, Khan Muhammad Waqas, Shah Aun Raza, Naveed Abdul Khaliq
Department of Biochemistry and Molecular Biology, Army Medical College, National University of Science & Technology, Rawalpindi, Pakistan.
J Ayub Med Coll Abbottabad. 2011 Jan-Mar;23(1):70-2.
Alanine Aminotransferase (ALT) is an enzyme found in liver and indicates injury to hepatocytes. It is influenced by various factors. The objectives of this study were to identify the correlates of ALT activity among healthy medical students of Army Medical College, National University of Sciences and Technology, aged 18-22 years. This was to establish the mean ALT levels of the students and compare them with those in various parts of the world and observe various correlations that exist and factors that may influence ALT levels.
This population included 143 volunteer students (93 men and 50 women) selected on the basis of negative answers to a detailed medical questionnaire including past medical history, drug and alcohol consumption, on the absence of clinical signs of liver disease, on the negativity of serological testing for Hepatitis B and C virus.
The mean ALT level of the entire population was 28.7 IU/L. A major sex-difference in ALT value was observed, the mean ALT value being higher in men than in women (32.1 +/- 21.7 vs. 22.6 +/- 9.7 IU/L, p<0.004). According to WHO criteria for Asians, normal BMI was taken from 18.5-23.0 Kg/m2. There was a positive significant correlation between serum ALT level and BMI (p<0.002). ALT level strongly correlates with body mass index and gender. There was no significant variation in ALT levels among Punjabis and Sindhis, Balochis, Pathans, and Kashmiris.
We suggest the need of taking into account these parameters in a clinical interpretation of ALT level.
丙氨酸转氨酶（ALT）是一种存在于肝脏中的酶，指示肝细胞损伤。它受多种因素影响。本研究的目的是确定国立科技大学陆军医学院18至22岁健康医学生中ALT活性的相关因素。这是为了确定这些学生ALT的平均水平，并与世界不同地区的水平进行比较，观察存在的各种相关性以及可能影响ALT水平的因素。
该人群包括143名志愿学生（93名男性和50名女性），他们是根据对一份详细的医学问卷（包括既往病史、药物和酒精消费情况）的否定回答、无肝病临床体征以及乙肝和丙肝病毒血清学检测呈阴性而挑选出来的。
整个人群ALT的平均水平为28.7 IU/L 。观察到ALT值存在显著的性别差异，男性的平均ALT值高于女性（32.1±21.7 vs. 22.6±9.7 IU/L，p<0.004）。根据世界卫生组织对亚洲人的标准 正常体重指数为18.5 - 23.0 Kg/m² 血清ALT水平与体重指数之间存在显著正相关（p<0.002）。ALT水平与体重指数和性别密切相关。旁遮普人、信德人、俾路支人、普什图人和克什米尔人之间的ALT水平没有显著差异。
我们建议在临床解释ALT水平时需要考虑这些参数。
