SAFU Department, Regina Elena Cancer Institute, Via delle Messi d'Oro 156, Rome 00158, Italy.
Future Oncol. 2012 Jul;8(7):829-37. doi: 10.2217/fon.12.64.
Electrochemotherapy is a tumor treatment that adapts the systemic or local delivery of anticancer drugs by the application of permeabilizing electric pulses with appropriate amplitude and waveforms. This allows the use of lipophobic drugs, which frequently have a narrow therapeutic index, with a decreased morbidity for the patient, while maintaining appropriate anticancer efficacy. Electrochemotherapy is used in humans for the treatment of cutaneous neoplasms or the palliation of skin tumor metastases, and a standard operating procedure has been devised. In veterinary oncology, the electrochemotherapy approach is gaining popularity, becoming a first-line treatment in consideration of its high efficacy and low toxicity. This review summarizes the state of the art in veterinary oncology as a preclinical model.
电化学疗法是一种肿瘤治疗方法，通过施加适当幅度和波形的透化电脉冲来实现抗癌药物的全身或局部输送。这使得可以使用疏水性药物，这些药物通常具有较窄的治疗指数，从而降低了患者的发病率，同时保持了适当的抗癌疗效。电化学疗法已在人类中用于治疗皮肤肿瘤或缓解皮肤肿瘤转移，并且已经制定了标准操作程序。在兽医肿瘤学中，电化学疗法方法越来越受欢迎，由于其高效和低毒性，成为一线治疗方法。本综述总结了作为临床前模型的兽医肿瘤学的最新技术。
