Spugnini Enrico Pierluigi, Baldi Alfonso
Biopulse srl, Via Toledo 256, Naples 80132, Italy.
Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Campania University "Luigi Vanvitelli", Via Vivaldi, 43, Caserta 81100, Italy.
Vet Clin North Am Small Anim Pract. 2019 Sep;49(5):967-979. doi: 10.1016/j.cvsm.2019.04.006. Epub 2019 Jun 6.
Tumor microenvironment represents a key obstacle for the effectiveness of anticancer drugs. Electrochemotherapy involves the systemic or local delivery of lipophobic drugs such as bleomycin and cisplatin, with the application of permeabilizing electric pulses having appropriate amplitude and waveforms. This greatly enhances the uptake of these drugs by an estimated factor of 700-fold for bleomycin and 4 to 8 times for cisplatin. Because of its efficacy and limited morbidity, this therapeutic option is becoming more and more available in veterinary oncology either as an adjuvant to surgery or as first line of treatment with palliative or curative purposes.
肿瘤微环境是抗癌药物有效性的关键障碍。电化学疗法涉及全身或局部递送亲脂性药物，如博来霉素和顺铂，并施加具有适当幅度和波形的透化电脉冲。这大大提高了这些药物的摄取量，博来霉素估计提高了700倍，顺铂提高了4至8倍。由于其疗效和有限的发病率，这种治疗选择在兽医肿瘤学中越来越多地作为手术辅助手段或作为姑息或治愈目的的一线治疗方法。
