罗他霉素与金黄色葡萄球菌核糖体的黏附结合。
Adhesive binding of rokitamycin to Staphylococcus aureus ribosomes.
作者信息
Endou K, Matsuoka M, Nakajima Y
机构信息
Division of Microbiology, Hokkaido Institute of Pharmaceutical Sciences, Japan.
出版信息
FEMS Microbiol Lett. 1990 Oct;60(1-2):93-6. doi: 10.1016/0378-1097(90)90351-p.
PMID:2283045
Abstract
Rokitamycin (RKM), a 3"-O-propionyl derivative of leucomycin A5, is bactericidal against staphylococci near the minimum inhibitory concentrations. RKM bound to ribosomes before-hand is only slightly displaced by erythromycin or josamycin, or even by RKM itself. The adhesive binding of the RKM-ribosome complex might prove to be the lethal event for susceptible staphylococci.
摘要
罗他霉素（RKM）是柱晶白霉素A5的3″-O-丙酰基衍生物，在接近最低抑菌浓度时对葡萄球菌具有杀菌作用。预先与核糖体结合的RKM仅被红霉素或交沙霉素轻微取代，甚至被RKM自身轻微取代。RKM-核糖体复合物的黏附性结合可能是敏感葡萄球菌的致死事件。
Zotero 插件