Brown K N
National Institute for Medical Research, London, U.K.
Immunol Lett. 1990 Aug;25(1-3):97-9. doi: 10.1016/0165-2478(90)90098-b.
Phenotypic antigenic variation within parasite strains and antigenic diversity between strains are important parameters in understanding the development of immunity to malaria. With the Plasmodium chabaudi chabaudi model in inbred mice, a combination of serological tests and DNA technology can be used to study the specificity of inducer and effector mechanisms in an infection with characteristics similar in many ways to those of P. falciparum in man.
寄生虫菌株内的表型抗原变异以及菌株间的抗原多样性是理解疟疾免疫发展的重要参数。利用近交系小鼠中的查巴迪疟原虫模型，血清学检测和DNA技术相结合可用于研究感染中诱导机制和效应机制的特异性，这种感染在许多方面具有与人类恶性疟原虫相似的特征。
