Orasch Christina, Conen Anna
Infectious Diseases Service and Hospital Epidemiology, University Hospital, Basel, Switzerland.
Scand J Infect Dis. 2012 Dec;44(12):987-91. doi: 10.3109/00365548.2012.697637. Epub 2012 Jul 25.
Primary cytomegalovirus (CMV) infection is rare in immunocompetent adults, even rarer in elderly patients. Little is known about the severity of symptoms and the clinical course in this patient group. In children and younger adults, CMV mostly presents as an asymptomatic disease or a self-limiting mild mononucleosis-like syndrome. We describe the clinical course of an unusually severe primary CMV infection in a 69-y-old otherwise healthy man, as well as 6 other severe cases in immunocompetent adults at our institution, and compare them to adult cases from the literature. CMV primary infection and antiviral treatment should be considered in immunocompetent elderly persons presenting with a severe mononucleosis-like syndrome.
原发性巨细胞病毒（CMV）感染在免疫功能正常的成年人中较为罕见，在老年患者中更为罕见。关于该患者群体中症状的严重程度和临床病程，我们知之甚少。在儿童和较年轻的成年人中，CMV大多表现为无症状疾病或自限性轻度单核细胞增多症样综合征。我们描述了一名69岁原本健康男性中异常严重的原发性CMV感染的临床病程，以及我们机构中免疫功能正常的成年人中的其他6例严重病例，并将它们与文献中的成人病例进行比较。对于出现严重单核细胞增多症样综合征的免疫功能正常的老年人，应考虑CMV原发性感染和抗病毒治疗。
