Second Infectious Diseases Division, INMI L.Spallanzani, 00149 Rome, Italy.
J Clin Virol. 2012 Dec;55(4):356-9. doi: 10.1016/j.jcv.2012.08.010. Epub 2012 Sep 10.
CMV infection is highly prevalent in general population and its clinical picture generally ranges from asymptomatic disease to mononucleosis-like syndrome. While severe life-threatening CMV disease is well documented in certain immunocompromised risk groups, severe infection with symptomatic pneumonia in immunocompetent hosts has been rarely documented. In this paper we describe a case of primary CMV infection, complicated by severe CMV pneumonia in an immunocompetent host, successfully treated with oral valganciclovir. Moreover, we reviewed CMV pneumonia cases in immunocompetent adults reported in the literature.
巨细胞病毒(CMV)感染在普通人群中非常普遍,其临床表现通常从无症状疾病到单核细胞增多症样综合征不等。虽然在某些免疫功能低下的高危人群中,严重的危及生命的 CMV 疾病已有充分记录,但在免疫功能正常的宿主中,伴有症状性肺炎的严重感染则很少有记录。在本文中,我们描述了一例免疫功能正常的宿主中发生的原发性 CMV 感染,并发严重的 CMV 肺炎,经口服缬更昔洛韦治疗后痊愈。此外,我们还回顾了文献中报道的免疫功能正常成年人的 CMV 肺炎病例。