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维生素D3调节胃癌和胆管癌中的细胞活力。

Vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma.

作者信息

Baek Sungmin, Lee Young-Suk, Shim Hye-Eun, Yoon Sik, Baek Sun-Yong, Kim Bong-Seon, Oh Sae-Ock

机构信息

Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea.

出版信息

Anat Cell Biol. 2011 Sep;44(3):204-9. doi: 10.5115/acb.2011.44.3.204. Epub 2011 Sep 29.

DOI:10.5115/acb.2011.44.3.204
PMID:22025972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3195824/
Abstract

A low serum level of vitamin D has been associated with an increased incidence of gastrointestinal tract cancers. However, the effects of vitamin D3 have not been investigated in gastric cancer and cholangiocarcinoma. In the present study, we found that vitamin D3 treatment significantly suppressed the viability of gastric cancer and cholangiocarcinoma cells. Moreover, vitamin D3 had a synergistic effect with other anti-cancer drugs, such as paclitaxel, adriamycin, and vinblastine, for suppressing cell viability. To determine the underlying mechanism involved in the regulation of viability by vitamin D3, we examined the effects of vitamin D3 on expression of hedgehog signaling target genes, which has been associated with gastric cancer and cholangiocarcinoma. Vitamin D3 treatment decreased the level of mRNA expression of patched1, Gli1, cyclin D1, and Bcl2, suggesting the possibility that vitamin D3 may act through regulation of hedgehog signaling. From the above results, we conclude that vitamin D3 regulates cell viability in gastric cancer and cholangiocarcinoma.

摘要

血清维生素D水平较低与胃肠道癌症发病率增加有关。然而，维生素D3对胃癌和胆管癌的影响尚未得到研究。在本研究中，我们发现维生素D3治疗可显著抑制胃癌和胆管癌细胞的活力。此外，维生素D3与其他抗癌药物（如紫杉醇、阿霉素和长春碱）在抑制细胞活力方面具有协同作用。为了确定维生素D3调节细胞活力的潜在机制，我们研究了维生素D3对刺猬信号通路靶基因表达的影响，这些基因与胃癌和胆管癌有关。维生素D3治疗降低了patched1、Gli1、细胞周期蛋白D1和Bcl2的mRNA表达水平，提示维生素D3可能通过调节刺猬信号通路发挥作用。根据上述结果，我们得出结论，维生素D3可调节胃癌和胆管癌的细胞活力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/5efe3d814879/acb-44-204-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/2f52d5c004a9/acb-44-204-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/e62a90022186/acb-44-204-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/5efe3d814879/acb-44-204-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/2f52d5c004a9/acb-44-204-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/e62a90022186/acb-44-204-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f280/3195824/5efe3d814879/acb-44-204-g003.jpg

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