University of Rochester Medical Center, Division of Plastic Surgery, NY, USA.
Int J Oral Maxillofac Surg. 2012 Oct;41(10):1244-7. doi: 10.1016/j.ijom.2012.06.022. Epub 2012 Jul 24.
A wide body of evidence shows that patients with clefts exhibit decreased growth in their early years. Less evidence regarding their growth trajectory, specifically their body mass indices (BMIs), in later years is available. This study analyzes BMIs of patients with isolated clefts and/or palate over time using age-adjusted BMI z-scores based on the CDC 2000 references for height and weight for age. At least two height and weight measurements were obtained during 2-10 years and at least two height and weight measurements were obtained during 10-20 years. Mean BMI z-score for all patients was 0.117. Males had a mean z-score of 0.087 and females a mean of 0.160 (p=0.407). Patients under 10 years of age had a mean z-score of 0.208, while patients older than 10 years had a mean z-score of -0.028 (p=0.223). While significance was not achieved in the statistical analysis, the results suggest that overall, the cleft population maintains a mean BMI that is similar to that of the general population during childhood and adolescence. A larger analysis is warranted to investigate this phenomenon further and to investigate specifically the rate of obesity within this group.
大量证据表明，唇腭裂患者在早期的生长发育中存在一定程度的受限。然而，关于他们在后期的生长轨迹，特别是体重指数（BMI）的相关证据相对较少。本研究使用基于美国疾病预防与控制中心（CDC）2000 年身高和体重参考标准的年龄调整 BMI z 分数，分析了单纯唇裂和（或）腭裂患者的 BMI 随时间的变化情况。这些患者在 2-10 岁期间至少接受过两次身高和体重测量，在 10-20 岁期间至少接受过两次身高和体重测量。所有患者的平均 BMI z 分数为 0.117。男性的平均 z 分数为 0.087，女性的平均 z 分数为 0.160（p=0.407）。10 岁以下患者的平均 z 分数为 0.208，而 10 岁以上患者的平均 z 分数为-0.028（p=0.223）。尽管在统计学分析中未达到显著性水平，但结果表明，总体而言，唇腭裂患者在儿童和青少年时期的 BMI 均值与普通人群相似。需要进行更大规模的分析来进一步研究这一现象，并专门研究该群体中肥胖的发生率。
