Bowers E J, Mayro R F, Whitaker L A, Pasquariello P S, LaRossa D, Randall P
Scand J Plast Reconstr Surg Hand Surg. 1987;21(1):7-14. doi: 10.3109/02844318709083572.
This paper discusses general body growth in children with craniofacial clefts. Body growth is important in such patients because morphology reflects the cumulation of metabolism over time. The same hormones that direct general body growth also govern the ontogeny of the head and face. Body growth varies in children with different types of clefts. We found no average differences from US norms for those with isolated clefts of the lip alone or those with bilateral clefts of the lip and palate. Children with unilateral clefts of the lip and palate and with isolated cleft palate were significantly shorter than their unaffected peers. Males with these defects were also thinner than normal based on average standard deviation scores for body mass indices. Both unilateral and bilateral clefts of the lip and palate predominated in males, while isolated cleft lip was more frequent in females. Our results indicate that congenital metabolic variation contributes to the development of orofacial clefting and influences postnatal development in certain types of cleft. Accordingly, cleft type is important to growth prognosis, and growth status is relevant to optimization of therapy in orofacial cleft patients.
本文讨论了患有颅面裂患儿的全身生长情况。全身生长在这类患者中很重要，因为形态反映了新陈代谢随时间的累积。指导全身生长的相同激素也控制着头面部的个体发育。不同类型腭裂患儿的身体生长情况各不相同。我们发现，单纯唇裂或双侧唇腭裂患儿与美国标准相比，平均身高没有差异。单侧唇腭裂和单纯腭裂患儿明显比未受影响的同龄人矮。根据体重指数的平均标准差得分，患有这些缺陷的男性也比正常人瘦。唇腭裂的单侧和双侧类型在男性中占主导，而单纯唇裂在女性中更为常见。我们的结果表明，先天性代谢变异促成了口面部裂隙的发生，并影响某些类型腭裂的出生后发育。因此，腭裂类型对生长预后很重要，而生长状况与口面部腭裂患者治疗的优化相关。
