García-Benítez Sergio, Fleck Steven J, Naclerio Fernando, Martín Miguel Angel, Lucia Alejandro
European University of Madrid, Madrid, Spain.
J Child Neurol. 2013 Jun;28(6):805-8. doi: 10.1177/0883073812451328. Epub 2012 Jul 25.
Owing to the risk of severe rhabdomyolysis, clinicians advise McArdle disease patients to refrain from strenuous exercise, particularly weight lifting. A 15-year-old male McArdle disease patient performed a 6-week, supervised, light- to moderate-intensity (~65-70% of one-repetition-maximum) resistance (weight lifting) training program (2 sessions/week). Training resulted in ~27% and ~6% increase in one-repetition-maximum bench press and multipower squat performance while inducing no myoglobinuria. The patient changed to a lower disease severity class, that is, he became virtually asymptomatic in terms of exercise limitations. The authors' preliminary data suggest that supervised, light to moderate resistance training is feasible in children with McArdle disease and has potential clinical benefits.
由于存在严重横纹肌溶解的风险，临床医生建议麦克尔迪氏病患者避免剧烈运动，尤其是举重。一名15岁的男性麦克尔迪氏病患者进行了为期6周的、有监督的、轻度至中度强度（约为一次最大重复量的65%-70%）的抗阻（举重）训练计划（每周2次）。训练使一次最大重复量卧推和多组深蹲成绩分别提高了约27%和约6%，同时未引发肌红蛋白尿。该患者的疾病严重程度等级降低，也就是说，在运动受限方面他几乎没有症状了。作者的初步数据表明，有监督的轻度至中度抗阻训练对患有麦克尔迪氏病的儿童是可行的，且具有潜在的临床益处。
