Pongsuvareeyakul Tip, Sukpan Kornkanok, Chaicharoen Somjet, Khunamornpong Surapan
Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Uttaradit Hospital, Uttaradit, Thailand.
Case Rep Pathol. 2017;2017:7907359. doi: 10.1155/2017/7907359. Epub 2017 Jul 2.
The occurrence of malignant transformation in mature cystic teratoma of the ovary is rare, with squamous cell carcinoma being the most common histologic type. Sarcomatous transformation has been rarely described in the literature. We present a case of leiomyosarcoma with a minor component of squamous cell carcinoma arising in mature cystic teratoma of ovary in a 65-year-old woman. The malignant tumor showed two distinct components of sarcomatous and invasive epithelial elements, which were confirmed by immunostaining. To our knowledge, only four cases of leiomyosarcoma in ovarian mature cystic teratoma have been reported and this is a unique case report of leiomyosarcoma and squamous cell carcinoma arising in a mature cystic teratoma of ovary.
卵巢成熟囊性畸胎瘤发生恶变罕见，其中鳞状细胞癌是最常见的组织学类型。肉瘤样变在文献中鲜有描述。我们报告一例65岁女性卵巢成熟囊性畸胎瘤中出现的平滑肌肉瘤，伴有少量鳞状细胞癌成分。该恶性肿瘤表现出肉瘤样和浸润性上皮成分这两种不同成分，经免疫染色得以证实。据我们所知，卵巢成熟囊性畸胎瘤中仅报道过4例平滑肌肉瘤，这是一例卵巢成熟囊性畸胎瘤中出现平滑肌肉瘤和鳞状细胞癌的独特病例报告。
