UPMC Paris 06, UMR-S 787, F-75013, Paris, France.
Development. 2012 Aug;139(16):2845-56. doi: 10.1242/dev.069088.
Following their discovery in 1961, it was speculated that satellite cells were dormant myoblasts, held in reserve until required for skeletal muscle repair. Evidence for this accumulated over the years, until the link between satellite cells and the myoblasts that appear during muscle regeneration was finally established. Subsequently, it was demonstrated that, when grafted, satellite cells could also self-renew, conferring on them the coveted status of 'stem cell'. The emergence of other cell types with myogenic potential, however, questioned the precise role of satellite cells. Here, we review recent recombination-based studies that have furthered our understanding of satellite cell biology. The clear consensus is that skeletal muscle does not regenerate without satellite cells, confirming their pivotal and non-redundant role.
自 1961 年被发现以来，人们推测卫星细胞是处于休眠状态的成肌细胞，储存在体内以备骨骼肌修复之用。多年来，这方面的证据不断积累，直到最终确定卫星细胞与肌肉再生过程中出现的成肌细胞之间的联系。随后，研究表明，当被移植时，卫星细胞也可以自我更新，使它们获得了“干细胞”这一令人梦寐以求的地位。然而，其他具有成肌潜能的细胞类型的出现，质疑了卫星细胞的确切作用。在这里，我们回顾了最近基于重组的研究，这些研究进一步加深了我们对卫星细胞生物学的理解。明确的共识是，如果没有卫星细胞，骨骼肌就不会再生，这证实了它们的关键和不可或缺的作用。
