Sawhney A S, Hubbell J A
Department of Chemical Engineering, University of Texas, Austin 78712-1062.
J Biomed Mater Res. 1990 Oct;24(10):1397-411. doi: 10.1002/jbm.820241011.
A series of 66 terpolymers of dl-lactide, glycolide, and epsilon-caprolactone was synthesized for the purpose of identifying those materials which exhibited rapid degradation in vitro. Polymers having half-lives from a few weeks to several months were identified. The morphology of each material was characterized by differential scanning calorimetry. A terpolymeric composition of 60% glycolide, 30% dl-lactide, and 10% epsilon-caprolactone, which exhibited a half-life of 17 days, was selected for further investigation. The hydrophilicity of this material was increased by performing the polymerization in the presence of a polyether prepolymer, Pluronic F-68, with the motivation of concomitantly reducing cell and tissue adhesion. An increase in the hydrophilicity of the material was apparent from contact angle measurements. Copolymerization with the prepolymer also resulted in a stronger and partly crystalline material which was mechanically stable at physiological temperature in water. A slight increase was observed in the half-life of the polymer relative to the base polymer due to the presence of the prepolymer.
合成了一系列由外消旋丙交酯、乙交酯和ε-己内酯组成的66种三元共聚物，目的是确定那些在体外表现出快速降解的材料。鉴定出了半衰期从几周到几个月不等的聚合物。通过差示扫描量热法对每种材料的形态进行了表征。选择了一种由60%乙交酯、30%外消旋丙交酯和10%ε-己内酯组成的三元共聚物组成，其半衰期为17天，用于进一步研究。通过在聚醚预聚物普朗尼克F-68存在下进行聚合反应来提高这种材料的亲水性，目的是同时减少细胞和组织的粘附。从接触角测量结果可以明显看出材料亲水性的增加。与预聚物的共聚还产生了一种更强且部分结晶的材料，该材料在生理温度的水中具有机械稳定性。由于预聚物的存在，相对于基础聚合物，聚合物的半衰期略有增加。
