Department of Internal Medicine, University Of Texas SW Medical Center, Dallas, Texas 75390-9030, USA.
J Clin Invest. 2012 Jun;122(6):1958-9. doi: 10.1172/jci63967.
In the catabolic state with no food intake, the liver generates ketones by breaking down fatty acids. During the nocturnal fast or longer starvation periods, this protects the brain, which cannot oxidize fatty acids. In 1977, we published a study in the JCI noting the surprising realization that malonyl-CoA, the substrate of fatty acid synthesis, was also an inhibitor of fatty acid oxidation. Subsequent experiments have borne out this finding and furthered our understanding of molecular metabolism.
在没有食物摄入的分解代谢状态下，肝脏通过分解脂肪酸生成酮体。在夜间禁食或更长时间的饥饿期间，这可以保护大脑，因为大脑无法氧化脂肪酸。1977 年，我们在《临床检查杂志》（JCI）上发表了一项研究，令人惊讶地发现，脂肪酸合成的底物丙二酰辅酶 A 也是脂肪酸氧化的抑制剂。随后的实验证实了这一发现，并进一步加深了我们对分子代谢的理解。
