Calleja Patricia, Huarte Judit, Agüeros Maite, Ruiz-Gatón Luisa, Espuelas Socorro, Irache Juan M
Department of Pharmacy & Pharmaceutical Technology, University of Navarra, 31080 Pamplona, Spain.
Ther Deliv. 2012 Jan;3(1):43-57. doi: 10.4155/tde.11.140.
The oral route is preferred by patients for drug administration due to its convenience, resulting in improved compliance. Unfortunately, for a number of drugs (e.g., anticancer drugs), this route of administration remains a challenge. Oral chemotherapy may be an attractive option and especially appropriate for chronic treatment of cancer. However, this route of administration is particularly complicated for the administration of anticancer drugs ascribed to Class IV of the Biopharmaceutical Classification System. This group of compounds is characterized by low aqueous solubility and low intestinal permeability. This review focuses on the use of cyclodextrins alone or in combination with bioadhesive nanoparticles for oral delivery of drugs. The state-of-the-art technology and challenges in this area is also discussed.
由于口服给药方便，患者更倾向于选择这种给药途径，从而提高了依从性。不幸的是，对于许多药物（如抗癌药物），这种给药途径仍然是一个挑战。口服化疗可能是一个有吸引力的选择，尤其适用于癌症的长期治疗。然而，对于生物药剂学分类系统IV类的抗癌药物来说，这种给药途径特别复杂。这类化合物的特点是水溶性低和肠道通透性低。本综述重点关注单独使用环糊精或与生物黏附纳米颗粒联合用于口服给药的情况。还讨论了该领域的最新技术和挑战。
