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用于药物递送与诊疗的环糊精基纳米颗粒

Cyclodextrin Based Nanoparticles for Drug Delivery and Theranostics.

作者信息

Gadade Dipak Dilip, Pekamwar Sanjay Sudhakar

机构信息

Department of Pharmaceutics, Shri Bhagwan College of Pharmacy, CIDCO, N-6, Dr. Y.S. Khedkar Marg, Aurangabad-431001, India.

School of Pharmacy, SRTM University,Vishnupuri, Nanded- 431606, India.

出版信息

Adv Pharm Bull. 2020 Jun;10(2):166-183. doi: 10.34172/apb.2020.022. Epub 2020 Feb 18.

DOI:10.34172/apb.2020.022
PMID:32373486
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7191229/
Abstract

Colloidal nanoparticulate technology has been described in the literature as a versatile drug delivery system. But it possesses some inherent lacunae in their formulation. Cyclodextrins (CDs) have been extensively reported for the solubility enhancement of poorly water-soluble drugs. The CDs can cause intervention in aspects related to nanoparticles (NPs) that include improving drug loading in nano-system, improving stability, site-specific/targeted drug delivery, improving solubility profile and absorption of the drug in nanosystem with consequent improvement in bioavailability, with the possibility of controlled release, safety and efficacy. They find application in for simultaneous diagnosis and therapeutics for better treatment procedures. The current communication is focused on the application of CDs to overcome troubles in nanoparticulate formulation and enhancement of their performance. It also envisages the theranostic aspects of CDs.

摘要

胶体纳米颗粒技术在文献中被描述为一种通用的药物递送系统。但其在制剂方面存在一些固有缺陷。环糊精（CDs）已被广泛报道可提高难溶性药物的溶解度。环糊精可对与纳米颗粒（NPs）相关的方面产生干预，包括提高纳米系统中的药物载量、提高稳定性、实现位点特异性/靶向药物递送、改善纳米系统中药物的溶解度和吸收情况，从而提高生物利用度，还具有控释、安全性和有效性的可能性。它们可应用于同时进行诊断和治疗，以实现更好的治疗程序。本通讯聚焦于环糊精在克服纳米颗粒制剂问题及提高其性能方面的应用。它还设想了环糊精的诊疗一体化方面。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/41f06d03cfb9/apb-10-166-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/fbbdd9a34583/apb-10-166-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/24b72837ee80/apb-10-166-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/113a52f653d3/apb-10-166-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/de63cd97ff7f/apb-10-166-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/41f06d03cfb9/apb-10-166-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/fbbdd9a34583/apb-10-166-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/24b72837ee80/apb-10-166-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/113a52f653d3/apb-10-166-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/de63cd97ff7f/apb-10-166-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b2/7191229/41f06d03cfb9/apb-10-166-g005.jpg

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