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用于肽递送的肠道受体靶向:一位专家对失败原因和新机遇的个人观点。

Intestinal receptor targeting for peptide delivery: an expert's personal perspective on reasons for failure and new opportunities.

作者信息

Russell-Jones Gregory

机构信息

Mentor Pharmaceutical Consulting Pty Ltd, 23 Greenfield Ave, Middle Cove, NSW 2068, Australia.

出版信息

Ther Deliv. 2011 Dec;2(12):1575-93. doi: 10.4155/tde.11.129.

DOI:10.4155/tde.11.129
PMID:22833983
Abstract

The technology has been available more than 25 years that would enable the oral delivery of vaccines, proteins and peptides, thus avoiding the need for injection. To this day, injection is still the mode of delivery, yet not the main mode of choice. This review focuses on several of the potential modes for oral delivery of peptides, proteins and vaccines. Additionally, the review will provide the reader with an insight into the problems and potential solutions for several of these modes of oral delivery of peptides and proteins.

摘要

能够实现口服疫苗、蛋白质和肽从而避免注射需求的技术已经问世超过25年了。时至今日,注射仍然是给药方式,但并非主要的选择方式。本综述聚焦于几种口服肽、蛋白质和疫苗的潜在方式。此外,该综述将让读者深入了解这些口服肽和蛋白质方式中的几种所存在的问题及潜在解决方案。

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