Swaan P W
Division of Pharmaceutics and Pharmaceutical Chemistry, The Ohio State University, Columbus 43210, USA.
Pharm Res. 1998 Jun;15(6):826-34. doi: 10.1023/a:1011908128045.
Receptor-mediated transport mechanisms provide a pathway for the trafficking of extracellular macromolecules into (endocytosis) and across (transcytosis) the cell. This comprises the binding of a ligand to a specific cell-surface receptor, clustering of the ligand-receptor complexes in endocytotic vesicles and vesicular sorting. This review focuses on recent advances in cellular and molecular biology pertaining to receptor-mediated endocytosis. A concise overview is presented of current and potential future applications of targeting to RME mechanisms to improve oral macromolecular drug delivery.
受体介导的转运机制为细胞外大分子进入细胞（内吞作用）和穿过细胞（转胞吞作用）提供了一条途径。这包括配体与特定细胞表面受体的结合、配体-受体复合物在胞吞小泡中的聚集以及小泡分选。本综述聚焦于与受体介导的内吞作用相关的细胞与分子生物学的最新进展。简要概述了靶向受体介导的内吞作用机制以改善口服大分子药物递送的当前及潜在未来应用。
