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经皮给予格拉司琼：在预防化疗引起的恶心和呕吐中的应用指南。

Transdermal granisetron: a guide to its use in preventing nausea and vomiting induced by chemotherapy.

机构信息

Adis, Auckland, New Zealand.

出版信息

CNS Drugs. 2012 Sep 1;26(9):787-90. doi: 10.2165/11209440-000000000-00000.

DOI:10.2165/11209440-000000000-00000
PMID:22834568
Abstract

Transdermal granisetron (Sancuso®) is effective in the prevention of nausea and vomiting in patients with cancer who are receiving moderately or highly emetogenic chemotherapy for 3-5 days. Transdermal granisetron is noninferior to oral granisetron in this indication, and is generally well tolerated in this indication. Thus, transdermal granisetron provides a convenient option for the prevention of chemotherapy-induced nausea and vomiting, with the potential to improve patient compliance.

摘要

透皮型格拉司琼（Sancuso®）对接受中高度致吐性化疗（3-5 天）的癌症患者预防恶心和呕吐有效。在该适应证中，透皮型格拉司琼不劣于口服格拉司琼，且在该适应证中总体耐受良好。因此，透皮型格拉司琼为预防化疗引起的恶心和呕吐提供了一种方便的选择，有可能提高患者的依从性。

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2
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本文引用的文献

1
Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized, double-blind, phase III study.经皮给予格拉司琼治疗中高度致吐性多日化疗引起的化疗所致恶心呕吐的疗效和耐受性：一项随机、双盲、III 期研究。
Support Care Cancer. 2011 Oct;19(10):1609-17. doi: 10.1007/s00520-010-0990-y. Epub 2010 Sep 12.
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Transdermal granisetron.经皮给予格拉司琼。
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急性和延迟性化疗引起的恶心和呕吐的管理：奈妥吡坦-帕洛诺司琼联合用药的作用
Ther Clin Risk Manag. 2016 May 2;12:693-9. doi: 10.2147/TCRM.S81126. eCollection 2016.
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A randomized study of the efficacy and safety of transdermal granisetron in the control of nausea and vomiting induced by moderately emetogenic chemotherapy in Korean patients.一项关于透皮应用格拉司琼对韩国患者中度致吐性化疗引起的恶心和呕吐进行控制的疗效及安全性的随机研究。
Support Care Cancer. 2015 Jun;23(6):1769-77. doi: 10.1007/s00520-014-2507-6. Epub 2014 Dec 3.
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Granisetron transdermal system improves refractory nausea and vomiting in gastroparesis.格拉司琼透皮贴剂改善胃轻瘫患者的难治性恶心和呕吐。
Dig Dis Sci. 2014 Jun;59(6):1231-4. doi: 10.1007/s10620-014-3097-3. Epub 2014 Mar 11.
化疗引起的恶心和呕吐的药物治疗：关注近期进展
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Chemotherapy-induced nausea and vomiting.化疗引起的恶心和呕吐。
N Engl J Med. 2008 Jun 5;358(23):2482-94. doi: 10.1056/NEJMra0706547.
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Chemotherapy-induced nausea and vomiting.化疗引起的恶心和呕吐。
Cancer J. 2008 Mar-Apr;14(2):85-93. doi: 10.1097/PPO.0b013e31816a0f07.
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Transdermal delivery of drugs for urologic applications: basic principles and applications.用于泌尿外科应用的药物经皮给药：基本原理与应用
Urology. 2006 Apr;67(4):657-64. doi: 10.1016/j.urology.2005.11.039.
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Drugs. 1991 Nov;42(5):805-24. doi: 10.2165/00003495-199142050-00007.