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放射性标记的脱蛋白黏蛋白SM3,用于卵巢肿瘤免疫闪烁显像的单克隆抗体。

Radiolabelled stripped mucin, SM3, monoclonal antibody for immunoscintigraphy of ovarian tumours.

作者信息

Granowska M, Mather S J, Jobling T, Naeem M, Burchell J, Taylor-Papadimitriou J, Shepherd J, Britton K E

机构信息

Department of Nuclear Medicine, St. Bartholomew's Hospital, London, England.

出版信息

Int J Biol Markers. 1990 Apr-Jun;5(2):89-96. doi: 10.1177/172460089000500208.

DOI:10.1177/172460089000500208
PMID:2283483
Abstract

A new monoclonal antibody, SM3, against stripped mucin core protein has been evaluated for the radioimmunoscintigraphy of ovarian cancer. It was radiolabelled with In-111, I-123 and Tc-99m and results showed a sensitivity of 95%, 100% and 100% and an accuracy of 73%, 86% and 100% for malignancy; respectively.

摘要

一种针对脱糖粘蛋白核心蛋白的新型单克隆抗体SM3已用于卵巢癌的放射免疫闪烁显像评估。它分别用铟-111、碘-123和锝-99m进行放射性标记,结果显示对恶性肿瘤的敏感性分别为95%、100%和100%,准确性分别为73%、86%和100%。

相似文献

1
Radiolabelled stripped mucin, SM3, monoclonal antibody for immunoscintigraphy of ovarian tumours.放射性标记的脱蛋白黏蛋白SM3,用于卵巢肿瘤免疫闪烁显像的单克隆抗体。
Int J Biol Markers. 1990 Apr-Jun;5(2):89-96. doi: 10.1177/172460089000500208.
2
Diagnostic evaluation of 111In and 99mTc radiolabelled monoclonal antibodies in ovarian and colorectal cancer: correlations with surgery.铟-111和锝-99m放射性标记单克隆抗体在卵巢癌和结直肠癌中的诊断评估:与手术的相关性
Int J Rad Appl Instrum B. 1991;18(4):413-24. doi: 10.1016/0883-2897(91)90069-w.
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Radioimmunoscintigraphy with Tc-99m-labelled SM3 in differentiating malignant from benign adnexal masses.用锝-99m标记的SM3进行放射免疫闪烁显像在鉴别附件肿块的良恶性方面的应用
BJOG. 2003 May;110(5):508-14.
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Radioimmunoscintigraphy of ovarian cancer.卵巢癌的放射免疫闪烁显像
Dis Markers. 1991 May-Aug;9(3-4):191-5.
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Kinetic analysis and probability mapping applied to the detection of ovarian cancer by radioimmunoscintigraphy.
J Nucl Med. 1988 May;29(5):599-607.
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Detection of tumours using radiolabelled antibodies.使用放射性标记抗体检测肿瘤。
Radiography. 1983 Jan;49(577):5-12.
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[The diagnostic value of immunoscintigraphy using the monoclonal antibody OV-TL3 in patients with ovarian carcinoma].[单克隆抗体OV-TL3免疫闪烁显像在卵巢癌患者中的诊断价值]
Ned Tijdschr Geneeskd. 1991 Jan 26;135(4):126-30.
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The implications of patient antibody response for the clinical usefulness of immunoscintigraphy.患者抗体反应对免疫闪烁显像临床应用价值的影响。
Nucl Med Commun. 1988 Apr;9(4):273-82.
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[The detection of metastases of ovarian carcinoma by immunoscintigraphy with monoclonal antibodies].[利用单克隆抗体免疫闪烁显像检测卵巢癌转移灶]
Akush Ginekol (Sofiia). 1990;29(1):57-60.
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Radioimmunodetection in patients with suspected ovarian cancer.疑似卵巢癌患者的放射免疫检测
J Nucl Med. 1985 Dec;26(12):1369-76.

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99mTc-labelled SM3 in the preoperative evaluation of axillary lymph nodes and primary breast cancer with change detection statistical processing as an aid to tumour detection.
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Radioimmunoscintigraphy with technetium-99m-labelled monoclonal antibody, SM3, in gynaecological cancer.用99m锝标记的单克隆抗体SM3进行放射免疫闪烁显像在妇科癌症中的应用
Eur J Nucl Med. 1993 Jun;20(6):483-9. doi: 10.1007/BF00175160.
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Peroperative radioimmunodetection of ovarian carcinoma using a hand-held gamma detection probe.使用手持式γ探测仪对卵巢癌进行术中放射免疫检测。
Br J Cancer. 1994 Dec;70(6):1263-6. doi: 10.1038/bjc.1994.484.
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