Department of Urology, University of Leipzig, Leipzig, Germany.
J Endourol. 2013 Jan;27(1):80-5. doi: 10.1089/end.2012.0262. Epub 2012 Sep 18.
Radical prostatectomy is the gold standard surgical treatment for organ-confined prostate cancer. There is no consensus on the impact of previous laparoscopic experience on the learning curve of robot-assisted laparoscopic prostatectomy (RALP). We compared the perioperative complications and early patient outcomes from our initial 100 cases of RALP with laparoscopic prostatectomy (LRP) cases performed well beyond the learning curve.
Between July 2011 and January 2012, 110 RALP were performed by one of two surgeons, each with previous experience of more than 1000 LRP. The cases were pair matched from among the last 208 patients who had undergone LRP by the same surgeons at the same time. The clinical parameters, operative details, postoperative complications, and short-term outcomes from these patients, collected prospectively, were compared between the two groups.
The prostate-specific antigen (PSA) level and age of the two groups was similar. The operative time (128.4 vs 153.9 min; P=0.01) and blood loss (200 vs 254 mL; P=0.01) was significantly less for the LRP group, but the duration of catheterization was similar (5.89 vs 6.2 days). The complication rate was low. No procedures needed conversions, and no patient had a visceral injury or blood transfusion. Twenty-three patients in the LRP group and 33 patients in the RALP group had extraprostatic disease, and the positive margin rate was 14% and 19% for these respective groups. At 3 months, PSA level was undetectable in 94% of LRP and 92% RALP patients, while 56% and 65% (P=0.062) patients in these groups were using 0 to 2 pads per day.
The initial results of the outcome of RALP are at least at par with those of LRP and with those of previously published RALP series. This suggests the lack of a steep learning curve for experienced laparoscopic surgeons in performing RALP.
根治性前列腺切除术是治疗局限性前列腺癌的金标准手术。对于之前的腹腔镜经验对机器人辅助腹腔镜前列腺切除术(RALP)学习曲线的影响,尚无共识。我们比较了我们最初的 100 例 RALP 与腹腔镜前列腺切除术(LRP)的围手术期并发症和早期患者结局,这些 LRP 病例的学习曲线已经远远超过。
在 2011 年 7 月至 2012 年 1 月期间,由两位外科医生之一进行了 110 例 RALP,每位外科医生之前都有超过 1000 例 LRP 的经验。从同一外科医生同时进行的最后 208 例 LRP 患者中,配对选择了这些病例。前瞻性收集这些患者的临床参数、手术细节、术后并发症和短期结果,并对两组进行比较。
两组的前列腺特异性抗原(PSA)水平和年龄相似。LRP 组的手术时间(128.4 分钟对 153.9 分钟;P=0.01)和出血量(200 毫升对 254 毫升;P=0.01)明显较少,但导尿管留置时间相似(5.89 天对 6.2 天)。并发症发生率较低。没有手术需要转换,没有患者发生内脏损伤或输血。LRP 组有 23 例和 RALP 组有 33 例患者有前列腺外疾病,这些组的阳性边缘率分别为 14%和 19%。在 3 个月时,LRP 组和 RALP 组分别有 94%和 92%的患者 PSA 水平无法检测到,而这些组中分别有 56%和 65%(P=0.062)的患者每天使用 0 到 2 个护垫。
RALP 的初始结果至少与 LRP 结果和之前发表的 RALP 系列结果相当。这表明,对于有经验的腹腔镜外科医生来说,执行 RALP 并没有陡峭的学习曲线。