Kempster P A, Frankel J P, Stern G M, Lees A J
Department of Neurology, Middlesex and Hospital School of Medicine, University College, London.
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):1004-7. doi: 10.1136/jnnp.53.11.1004.
The magnitude and pattern of motor responses to single doses of subcutaneous apomorphine and oral levodopa were compared in 14 patients with Parkinson's disease. Although apomorphine produced much shorter motor responses than levodopa, the quality of response to the two drugs was virtually indistinguishable. These clinical observations support the notion that integrity of striatal post-synaptic dopamine receptors is a key determinant of responsiveness to dopaminergic treatment in Parkinson's disease.
在14例帕金森病患者中比较了单次皮下注射阿扑吗啡和口服左旋多巴后运动反应的程度和模式。尽管阿扑吗啡产生的运动反应比左旋多巴短得多，但对这两种药物的反应质量几乎无法区分。这些临床观察结果支持这样一种观点，即纹状体突触后多巴胺受体的完整性是帕金森病对多巴胺能治疗反应性的关键决定因素。
