Frankel J P, Pirtosek Z, Kempster P A, Bovingdon M, Webster R, Lees A J, Stern G M
Department of Neurology, Middlesex and University College Hospitals School of Medicine, London.
J Neurol Neurosurg Psychiatry. 1990 Nov;53(11):948-50. doi: 10.1136/jnnp.53.11.948.
Diurnal differences in duration and quality of motor response to levodopa are frequently described by patients. The quality and duration of motor responses were objectively assessed to morning and afternoon oral levodopa doses in five patients with Parkinsonian motor fluctuations who complained of diurnal variation in response to their normal levodopa medication. Results suggest that under controlled conditions which eliminated the effects of diet and overlapping levodopa effects the response to levodopa remained unchanged throughout the day, and that the duration of response could be predicted by plasma levodopa levels.
患者经常描述左旋多巴运动反应的持续时间和质量存在昼夜差异。对五名患有帕金森病运动波动且抱怨其正常左旋多巴药物反应存在昼夜变化的患者，客观评估了其对早晨和下午口服左旋多巴剂量的运动反应的质量和持续时间。结果表明，在消除饮食和左旋多巴重叠效应影响的受控条件下，左旋多巴的反应在一天中保持不变，并且反应持续时间可以通过血浆左旋多巴水平预测。
