van Hilten J J, Hoogland G, van der Velde E A, Middelkoop H A, Kerkhof G A, Roos R A
Department of Neurology, Academic Hospital, Leiden, The Netherlands.
J Neurol Neurosurg Psychiatry. 1993 Aug;56(8):874-7. doi: 10.1136/jnnp.56.8.874.
Wrist motor activity was monitored continuously in 65 patients with Parkinson's disease (PD) to assess the influence of disease severity and excessive fatigue on the diurnal motor activity pattern. Mildly or moderately affected PD patients had a similar diurnal pattern to that of 68 healthy controls, with a late morning peak; however, mean levels of motor activity were lower. The most severely affected patients showed an overall flattened diurnal pattern. Results refute the existence of end of day deterioration, but instead suggest a "depressed morning start" in the most severely affected patients with PD. Excessive fatigue was not reported at a particular time of day and did not influence the diurnal motor activity pattern.
对65例帕金森病（PD）患者的腕部运动活动进行了持续监测，以评估疾病严重程度和过度疲劳对昼夜运动活动模式的影响。轻度或中度受影响的PD患者与68名健康对照者具有相似的昼夜模式，上午晚些时候出现峰值；然而，运动活动的平均水平较低。受影响最严重的患者表现出整体平坦的昼夜模式。结果反驳了一天结束时病情恶化的存在，而是表明在受影响最严重的PD患者中存在“早晨开始时情绪低落”。未在一天中的特定时间报告过度疲劳，且过度疲劳不影响昼夜运动活动模式。
