在超声条件下，以四氯化硅为催化剂，在水中高效合成新型 1-酰胺基-2-萘基胺。
Silica chloride catalyzed efficient route to novel 1-amidoalkyl-2-naphthylamines under sonic condition in water.
机构信息
Department of Studies in Chemistry, Bangalore University, Central College Campus, Bengaluru, India.
出版信息
Ultrason Sonochem. 2013 Jan;20(1):303-7. doi: 10.1016/j.ultsonch.2012.06.008. Epub 2012 Jun 28.
Abstract
A one-pot three-component condensation of an aldehyde, 2-naphthylamine, and acetamide has been achieved by sonication at 35 kHz. The reaction is catalysed by silica chloride in aqueous medium. This protocol afforded corresponding 1-amidoalkyl-2-naphthylamines in shorter reaction durations, and in high yields. The method involves simple work-up procedure, and avoids use of hazardous reagents.
摘要
在 35 kHz 的超声条件下，通过醛、2-萘胺和乙酰胺的一锅三步缩合反应实现了这一过程。反应在水相介质中以三氯化硅作为催化剂。该方案在更短的反应时间内以高产率得到相应的 1-酰胺基烷基-2-萘胺。该方法涉及简单的后处理步骤，避免了使用危险试剂。
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