生长因子对牙源性干/祖细胞的影响。
Effects of growth factors on dental stem/progenitor cells.
作者信息
Kim Sahng G, Zhou Jian, Solomon Charles, Zheng Ying, Suzuki Takahiro, Chen Mo, Song Songhee, Jiang Nan, Cho Shoko, Mao Jeremy J
机构信息
Center for Craniofacial Regeneration, Columbia University, 630 West 168 Street, PH7E, New York, NY 10032, USA.
出版信息
Dent Clin North Am. 2012 Jul;56(3):563-75. doi: 10.1016/j.cden.2012.05.001.
Abstract
The primary goal of regenerative endodontics is to restore the vitality and functions of the dentin-pulp complex, as opposed to filing of the root canal with bioinert materials. A myriad of growth factors regulates multiple cellular functions including migration, proliferation, differentiation, and apoptosis of several cell types intimately involved in dentin-pulp regeneration. Recent work showing that growth factor delivery, without cell transplantation, can yield pulp-dentin-like tissues in vivo provides one of the tangible pathways for regenerative endodontics. This review synthesizes knowledge on many growth factors that are known or anticipated to be efficacious in dental pulp-dentin regeneration.
摘要
再生牙髓治疗的主要目标是恢复牙本质-牙髓复合体的活力和功能，这与用生物惰性材料充填根管相反。多种生长因子调节多种细胞功能，包括与牙本质-牙髓再生密切相关的几种细胞类型的迁移、增殖、分化和凋亡。最近的研究表明，在不进行细胞移植的情况下递送生长因子可在体内产生牙髓-牙本质样组织，这为再生牙髓治疗提供了一条切实可行的途径。本综述综合了许多已知或预期对牙髓-牙本质再生有效的生长因子的相关知识。
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