间充质干细胞在口腔和全身性疾病中的治疗潜力。
Therapeutic potential of mesenchymal stem cells for oral and systemic diseases.
作者信息
Kim Reuben H, Mehrazarin Shebli, Kang Mo K
机构信息
Division of Restorative Dentistry, University of California Los Angeles School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
出版信息
Dent Clin North Am. 2012 Jul;56(3):651-75. doi: 10.1016/j.cden.2012.05.006.
Abstract
Mesenchymal stem cells (MSCs) are adult stem cells whose self-renewal, multipotency, and immunosuppressive functions have been investigated for therapeutic applications. MSCs have used for various systemic organ regenerative therapies, allowing rescue of tissue function in damaged or failing organs. This article reviews the regenerative and immunomodulatory functions of MSCs and their applications in dental, orofacial, and systemic tissue regeneration and treatment of inflammatory disorders. It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations.
摘要
间充质干细胞（MSCs）是成体干细胞，其自我更新、多能性和免疫抑制功能已被研究用于治疗应用。MSCs已被用于各种系统性器官再生疗法，可挽救受损或功能衰竭器官的组织功能。本文综述了MSCs的再生和免疫调节功能及其在牙齿、口腔颌面和全身组织再生以及炎症性疾病治疗中的应用。它还探讨了由于组织和MSC老化以及宿主对同种异体MSC移植的免疫反应而导致的MSC介导治疗面临的挑战，并讨论了旨在克服这些限制的MSCs替代来源。
相似文献
1
Therapeutic potential of mesenchymal stem cells for oral and systemic diseases.间充质干细胞在口腔和全身性疾病中的治疗潜力。
Dent Clin North Am. 2012 Jul;56(3):651-75. doi: 10.1016/j.cden.2012.05.006.
2
Mesenchymal stem cell-mediated treatment of oral diseases.间充质干细胞介导的口腔疾病治疗
Histol Histopathol. 2014 Aug;29(8):1007-15. doi: 10.14670/HH-29.1007. Epub 2014 Mar 17.
3
Dental Tissue-Derived Mesenchymal Stem Cells: Applications in Tissue Engineering.牙源性间充质干细胞：在组织工程中的应用
Crit Rev Biomed Eng. 2018;46(5):429-468. doi: 10.1615/CritRevBiomedEng.2018027342.
4
Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine.成人间充质干细胞及其外泌体：来源、特性及在再生医学中的应用。
Life Sci. 2020 Sep 1;256:118002. doi: 10.1016/j.lfs.2020.118002. Epub 2020 Jun 29.
5
Recent Advances in Endocrine, Metabolic and Immune Disorders: Mesenchymal Stem Cells (MSCs) and Engineered Scaffolds.内分泌、代谢及免疫紊乱的最新进展：间充质干细胞（MSCs）与工程支架
Endocr Metab Immune Disord Drug Targets. 2018;18(5):466-469. doi: 10.2174/1871530318666180423102905.
6
A Systemic Review of Adult Mesenchymal Stem Cell Sources and their Multilineage Differentiation Potential Relevant to Musculoskeletal Tissue Repair and Regeneration.成人间充质干细胞来源及其与肌肉骨骼组织修复和再生相关的多向分化潜能的系统评价。
Curr Stem Cell Res Ther. 2017;12(8):601-610. doi: 10.2174/1574888X12666170608124303.
7
Mesenchymal stem cells for tissue engineering and regenerative medicine.用于组织工程和再生医学的间充质干细胞。
Biomed Mater. 2006 Jun;1(2):63-71. doi: 10.1088/1748-6041/1/2/003. Epub 2006 Apr 26.
8
Stem cells in regenerative dentistry: Current understanding and future directions.再生牙科学中的干细胞：当前认识和未来方向。
J Oral Biosci. 2024 Jun;66(2):288-299. doi: 10.1016/j.job.2024.02.006. Epub 2024 Feb 23.
9
Dental Pulp Stem Cell-Derived Conditioned Medium: An Attractive Alternative for Regenerative Therapy.牙髓干细胞衍生条件培养液：再生治疗的有吸引力的选择。
Tissue Eng Part B Rev. 2019 Feb;25(1):78-88. doi: 10.1089/ten.TEB.2018.0168. Epub 2018 Oct 9.
10
Regenerative Medicine Applications of Mesenchymal Stem Cells.间充质干细胞的再生医学应用。
Adv Exp Med Biol. 2018;1089:115-141. doi: 10.1007/5584_2018_213.
引用本文的文献
1
Stromal cell therapy in cats with feline chronic gingivostomatitis: current perspectives and future direction.猫慢性龈口炎的间质细胞治疗：当前的观点和未来的方向。
J Feline Med Surg. 2023 Aug;25(8):1098612X231185395. doi: 10.1177/1098612X231185395.
2
Guanylate-Binding Protein 1 Promotes Migration and Invasion of Human Periodontal Ligament Stem Cells.鸟苷酸结合蛋白1促进人牙周膜干细胞的迁移和侵袭。
Stem Cells Int. 2018 Nov 28;2018:6082956. doi: 10.1155/2018/6082956. eCollection 2018.
3
Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.FBXO5 两个转录本促进人牙周膜间充质干细胞的迁移和成骨分化。
Biomed Res Int. 2018 Apr 19;2018:7849294. doi: 10.1155/2018/7849294. eCollection 2018.
4
Characterization of the osteogenic potential of mesenchymal stem cells from human periodontal ligament based on cell surface markers.基于细胞表面标志物对人牙周膜间充质干细胞成骨潜能的表征
Int J Oral Sci. 2015 Dec 18;7(4):213-9. doi: 10.1038/ijos.2015.42.
5
Odontogenic epithelial stem cells: hidden sources.牙源性上皮干细胞：隐藏的来源。
Lab Invest. 2015 Dec;95(12):1344-52. doi: 10.1038/labinvest.2015.108. Epub 2015 Sep 14.
6
Stem cell therapy: A novel treatment approach for oral mucosal lesions.干细胞疗法：一种治疗口腔黏膜病变的新方法。
J Pharm Bioallied Sci. 2015 Jan-Mar;7(1):2-8. doi: 10.4103/0975-7406.149809.
7
Development of oral osteomucosal tissue constructs in vitro and localization of fluorescently-labeled bisphosphonates to hard and soft tissue.口腔骨黏膜组织构建体的体外发育以及荧光标记双膦酸盐在硬组织和软组织中的定位。
Int J Mol Med. 2014 Aug;34(2):559-63. doi: 10.3892/ijmm.2014.1802. Epub 2014 Jun 11.
本文引用的文献
1
Umbilical cord-derived mesenchymal stem cells: strategies, challenges, and potential for cutaneous regeneration.脐带间充质干细胞：策略、挑战与皮肤再生潜能。
Front Med. 2012 Mar;6(1):41-7. doi: 10.1007/s11684-012-0175-9. Epub 2012 Mar 31.
2
Malignant germ cell-like tumors, expressing Ki-1 antigen (CD30), are revealed during in vivo differentiation of partially reprogrammed human-induced pluripotent stem cells.部分重编程的人诱导多能干细胞体内分化过程中，表达 Ki-1 抗原（CD30）的恶性生殖细胞样肿瘤被揭示。
Am J Pathol. 2012 May;180(5):2084-96. doi: 10.1016/j.ajpath.2012.01.011. Epub 2012 Mar 13.
3
Glucose-stimulated insulin secretion of various mesenchymal stem cells after insulin-producing cell differentiation.经胰岛细胞分化后各种间充质干细胞的葡萄糖刺激胰岛素分泌。
J Biosci Bioeng. 2012 Jun;113(6):771-7. doi: 10.1016/j.jbiosc.2012.02.007. Epub 2012 Mar 16.
4
Intravenous injection of mesenchymal stem cells is effective in treating liver fibrosis.静脉注射间充质干细胞对治疗肝纤维化有效。
World J Gastroenterol. 2012 Mar 14;18(10):1048-58. doi: 10.3748/wjg.v18.i10.1048.
5
Chitosan/collagen scaffold containing bone morphogenetic protein-7 DNA supports dental pulp stem cell differentiation in vitro and in vivo.壳聚糖/胶原支架负载骨形态发生蛋白 7 基因促进牙髓干细胞的体内外分化。
J Biomed Mater Res A. 2020 Dec;108(12):2519-2526. doi: 10.1002/jbm.a.34064. Epub 2012 Feb 18.
6
New approach to isolate mesenchymal stem cell (MSC) from human umbilical cord blood.从人脐带血中分离间充质干细胞（MSC）的新方法。
Cell Biol Int. 2012 Jul;36(7):595-600. doi: 10.1042/CBI20110336.
7
Systemic administration of autologous adipose-derived mesenchymal stem cells alleviates hepatic ischemia-reperfusion injury in rats.自体脂肪来源间充质干细胞系统给药可减轻大鼠肝缺血再灌注损伤。
Crit Care Med. 2012 Apr;40(4):1279-90. doi: 10.1097/CCM.0b013e31823dae23.
8
Conversion from human haematopoietic stem cells to keratinocytes requires keratinocyte secretory factors.从人类造血干细胞向角质细胞的转化需要角质细胞分泌因子。
Clin Exp Dermatol. 2012 Aug;37(6):658-64. doi: 10.1111/j.1365-2230.2011.04312.x. Epub 2012 Feb 14.
9
Allogeneic transplantation of umbilical cord-derived mesenchymal stem cells for diffuse alveolar hemorrhage in systemic lupus erythematosus.同种异体脐带间充质干细胞移植治疗系统性红斑狼疮弥漫性肺泡出血。
Clin Rheumatol. 2012 May;31(5):841-6. doi: 10.1007/s10067-012-1943-2.
10
Mesenchymal stem cells induce functionally active T-regulatory lymphocytes in a paracrine fashion and ameliorate experimental autoimmune uveitis.间充质干细胞通过旁分泌方式诱导功能活跃的 T 调节性淋巴细胞，并改善实验性自身免疫性葡萄膜炎。
Invest Ophthalmol Vis Sci. 2012 Feb 16;53(2):786-93. doi: 10.1167/iovs.11-8211. Print 2012 Feb.
Zotero 插件