Kim Reuben H, Mehrazarin Shebli, Kang Mo K
Division of Restorative Dentistry, University of California Los Angeles School of Dentistry, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA.
Dent Clin North Am. 2012 Jul;56(3):651-75. doi: 10.1016/j.cden.2012.05.006.
Mesenchymal stem cells (MSCs) are adult stem cells whose self-renewal, multipotency, and immunosuppressive functions have been investigated for therapeutic applications. MSCs have used for various systemic organ regenerative therapies, allowing rescue of tissue function in damaged or failing organs. This article reviews the regenerative and immunomodulatory functions of MSCs and their applications in dental, orofacial, and systemic tissue regeneration and treatment of inflammatory disorders. It also addresses challenges to MSC-mediated therapeutics arising from tissue and MSC aging and host immune response against allogenic MSC transplantation, and discusses alternative sources of MSCs aimed at overcoming these limitations.
间充质干细胞（MSCs）是成体干细胞，其自我更新、多能性和免疫抑制功能已被研究用于治疗应用。MSCs已被用于各种系统性器官再生疗法，可挽救受损或功能衰竭器官的组织功能。本文综述了MSCs的再生和免疫调节功能及其在牙齿、口腔颌面和全身组织再生以及炎症性疾病治疗中的应用。它还探讨了由于组织和MSC老化以及宿主对同种异体MSC移植的免疫反应而导致的MSC介导治疗面临的挑战，并讨论了旨在克服这些限制的MSCs替代来源。
