Department of Basic Medical Science, Ajman University of Science and Technology-Fujairah Campus, Al Fujairah, United Arab Emirates.
Department of Surgical Sciences, Ajman University of Science and Technology, Ajman, United Arab Emirates.
Lab Invest. 2015 Dec;95(12):1344-52. doi: 10.1038/labinvest.2015.108. Epub 2015 Sep 14.
The ultimate goal of dental stem cell research is to construct a bioengineered tooth. Tooth formation occurs based on the well-organized reciprocal interaction of epithelial and mesenchymal cells. The dental mesenchymal stem cells are the best explored, but because the human odontogenic epithelium is lost after the completion of enamel formation, studies on these cells are scarce. The successful creation of a bioengineered tooth is achievable only when the odontogenic epithelium is reconstructed to produce a replica of natural enamel. This article discusses the untapped sources of odontogenic epithelial stem cells in humans, such as those present in the active dental lamina in postnatal life, in remnants of dental lamina (the gubernaculum cord), in the epithelial cell rests of Malassez, and in reduced enamel epithelium. The possible uses of these stem cells in regenerative medicine, not just for enamel formation, are discussed.
牙干细胞研究的最终目标是构建生物工程牙齿。牙齿的形成是基于上皮细胞和间充质细胞的有序相互作用。牙间充质干细胞是研究最多的，但由于人类牙源性上皮在釉质形成后丧失，因此对这些细胞的研究很少。只有当牙源性上皮被重建以产生天然釉质的复制品时，才能成功地创建生物工程牙齿。本文讨论了人类牙源性上皮干细胞的未开发来源，如在出生后生命中的活跃牙板、牙板残迹（ gubernaculum 索）、Malassez 上皮细胞残余物和釉质上皮中存在的干细胞。讨论了这些干细胞在再生医学中的可能用途，不仅用于釉质形成。
