Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA.
Vet J. 2013 Jan;195(1):73-9. doi: 10.1016/j.tvjl.2012.06.034. Epub 2012 Jul 24.
The objective of this study was to characterize the clinical, clinicopathological, and histopathological findings of dogs with chronic pancreatitis. The necropsy database at Texas A&M University was searched for reports of dogs with histological evidence of chronic pancreatitis defined as irreversible histologic changes of the pancreas (i.e. fibrosis or atrophy). A reference necropsy population of 100 randomly selected dogs was used for signalment and concurrent disease comparisons. Cases were categorized as clinical or incidental chronic pancreatitis based on the presence of vomiting, decreased appetite, or both vs. neither of these signs. All archived pancreas samples were scored histologically using a published scoring system. Sixty-one dogs with chronic pancreatitis were included. The most frequent clinical signs were lethargy, decreased appetite, vomiting, and diarrhea. Compared to the reference necropsy population, chronic pancreatitis cases were more likely to be older, neutered, of the non-sporting/toy breed group, and to have concurrent endocrine, hepatobiliary, or neurological disease. Clinical cases had significantly higher histological scores for pancreatic necrosis and peripancreatic fat necrosis, and were significantly more likely to have hepatobiliary or endocrine disease as well as increased liver enzyme activities, or elevated cholesterol and bilirubin concentrations. In conclusion, clinical disease resulting from chronic pancreatitis might be related to the presence of pancreatic necrosis and pancreatic fat necrosis. The signalment, presentation, and concurrent diseases of dogs with chronic pancreatitis are similar to those previously reported for dogs with acute pancreatitis.
本研究旨在描述患有慢性胰腺炎犬的临床、临床病理和组织病理学表现。德克萨斯农工大学的剖检数据库中搜索了组织学证据表明患有慢性胰腺炎的犬的报告，这些犬的胰腺存在不可逆的组织学变化（即纤维化或萎缩）。选择了 100 只随机选择的犬作为参考剖检群体，用于比较特征和并发疾病。根据是否存在呕吐、食欲减退或两者都有与都没有这些症状，将病例分为临床或偶发性慢性胰腺炎。所有存档的胰腺样本均使用已发表的评分系统进行组织学评分。共纳入 61 只患有慢性胰腺炎的犬。最常见的临床症状是嗜睡、食欲减退、呕吐和腹泻。与参考剖检群体相比，慢性胰腺炎病例更可能是老年犬、绝育犬、非运动/玩具犬种，并且并发内分泌、肝胆或神经疾病。临床病例的胰腺坏死和胰周脂肪坏死的组织学评分明显更高，并且更有可能患有肝胆或内分泌疾病，以及肝酶活性升高或胆固醇和胆红素浓度升高。总之，由慢性胰腺炎引起的临床疾病可能与胰腺坏死和胰腺脂肪坏死的存在有关。患有慢性胰腺炎犬的特征、表现和并发疾病与先前报道的急性胰腺炎犬相似。
