Pápa Kinga, Máthé Akos, Abonyi-Tóth Zsolt, Sterczer Agnes, Psáder Roland, Hetyey Csaba, Vajdovich Péter, Vörös Károly
Department and Clinic of Internal Medicine, Szent István University, Budapest, Hungary.
Acta Vet Hung. 2011 Mar;59(1):37-52. doi: 10.1556/AVet.59.2011.1.4.
Medical records of 80 dogs diagnosed with acute pancreatitis during a 4-year period were evaluated regarding history, breed predilection, clinical signs and additional examination findings. Cases were selected if compatible clinical symptoms, increased serum activity of amylase or lipase and morphologic evidence of pancreatitis by ultrasonography, laparotomy or necropsy were all present. Like in other studies, neutered dogs had an increased risk of developing acute pancreatitis. Although breed predilection was consistent with earlier reports, some notable differences were also observed. Apart from Dachshunds, Poodles, Cocker Spaniels and Fox Terriers, the sled dogs (Laikas, Alaskan Malamutes) also demonstrated a higher risk for pancreatitis according to our results. Concurrent diseases occurred in 56 dogs (70%), diabetes mellitus (n = 29, 36%) being the most common. Clinical signs of acute pancreatitis were similar to those observed in other studies. The study group represented a dog population with severe acute pancreatitis, having a relatively high mortality rate (40%) compared to data of the literature. Breed, age, gender, neutering and body condition had no significant association with the outcome. Hypothermia (p = 0.0413) and metabolic acidosis (p = 0.0063) correlated significantly with poor prognosis and may serve as valuable markers for severity assessment in canine acute pancreatitis.
对80只在4年期间被诊断为急性胰腺炎的犬只的病历进行了评估,内容包括病史、品种易感性、临床症状和其他检查结果。如果同时出现符合的临床症状、淀粉酶或脂肪酶血清活性升高以及通过超声检查、剖腹手术或尸检发现的胰腺炎形态学证据,则选择这些病例。与其他研究一样,绝育犬患急性胰腺炎的风险增加。虽然品种易感性与早期报告一致,但也观察到了一些显著差异。根据我们的结果,除了腊肠犬、贵宾犬、可卡犬和猎狐梗外,雪橇犬(莱卡犬、阿拉斯加雪橇犬)患胰腺炎的风险也较高。56只犬(70%)出现并发疾病,其中糖尿病(n = 29,36%)最为常见。急性胰腺炎的临床症状与其他研究中观察到的相似。该研究组代表了患有严重急性胰腺炎的犬类群体,与文献数据相比,死亡率相对较高(40%)。品种、年龄、性别、绝育状态和身体状况与预后无显著关联。体温过低(p = 0.0413)和代谢性酸中毒(p = 0.0063)与预后不良显著相关,可作为犬急性胰腺炎严重程度评估的重要指标。