Department of Ophthalmology, Eye and Ear Nose and Throat Hospital of Fudan University, Shanghai, China.
Invest Ophthalmol Vis Sci. 2012 Aug 17;53(9):5722-7. doi: 10.1167/iovs.11-9094.
To determine vision-related quality of life (QoL) measured with the National Eye Institute Visual Function Questionnaire (NEI-VFQ) and the Ocular Surface Disease Index (OSDI) in dry eye patients, and establish potential correlations with the Zung Self Rating Anxiety Scales (SAS), the Zung Self Rating Depression Scales (SDS), ocular surface parameters, and sociodemographic measures.
The comparative study included 87 dry eye patients and 71 healthy volunteers who visited the department of ophthalmology, Eye and Ear Nose and Throat (EENT) Hospital of Fudan University, Shanghai, China, between June 2009 and December 2009. Surveys were administered to participants to evaluate their sociodemographic characteristics and disease-related factors. Data collected from the NEI-VFQ and OSDI survey instruments were analyzed to identify potential differences between the dry eye group and the control group. Correlations with sociodemographic characteristics, clinical parameters, and psychological status were evaluated.
Compared with the control group, our patient group had lower (worse) NEI-VFQ scores for the subscales of general health, general vision, ocular pain, short distance vision activities, long distance vision activities, vision related social function, vision related mental health, vision related role difficulties, vision related dependency, and driving (all P < 0.05), and higher (worse) OSDI composite and subscale scores of ocular symptoms, vision-related function, and environmental triggers (all P < 0.001). Significant correlations were found between QoL scores and patient anxiety and depression levels.
Vision-related QoL in dry eye patients was impaired and was correlated with anxiety and depression, further implicating this condition as an important public health problem deserving increased attention and resources.
使用国家眼科研究所视觉功能问卷（NEI-VFQ）和眼表疾病指数（OSDI）评估干眼症患者的视觉相关生活质量（QoL），并确定其与焦虑自评量表（SAS）、抑郁自评量表（SDS）、眼表参数和社会人口学测量值的潜在相关性。
这项比较研究纳入了 2009 年 6 月至 12 月期间在中国上海复旦大学眼耳鼻喉科医院就诊的 87 例干眼症患者和 71 名健康志愿者。向参与者发放调查问卷，以评估其社会人口学特征和疾病相关因素。分析来自 NEI-VFQ 和 OSDI 调查工具的数据，以确定干眼症组和对照组之间的潜在差异。评估与社会人口学特征、临床参数和心理状态的相关性。
与对照组相比，我们的患者组在一般健康、一般视力、眼部疼痛、近距离视力活动、远距离视力活动、视力相关社会功能、视力相关心理健康、视力相关角色困难、视力相关依赖和驾驶等方面的 NEI-VFQ 子量表评分较低（更差）（均 P < 0.05），在眼部症状、视力相关功能和环境触发等方面的 OSDI 综合和子量表评分较高（均 P < 0.001）。QoL 评分与患者的焦虑和抑郁水平显著相关。
干眼症患者的视觉相关 QoL 受损，与焦虑和抑郁相关，这进一步表明这种情况是一个重要的公共卫生问题，值得更多关注和资源投入。
