杠柳提取物对 NIDDM 大鼠胃溃疡的保护作用：胃黏膜糖蛋白和抗氧化剂的作用。

Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants.

机构信息

P. E. Society's Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

出版信息

Asian Pac J Trop Med. 2012 Aug;5(8):610-5. doi: 10.1016/S1995-7645(12)60126-6.

DOI:10.1016/S1995-7645(12)60126-6

PMID:22840448

Abstract

OBJECTIVE

To study the comparative gastroprotective effect of Luffa acutangula methanolic extract (LAM) and aqueous extract (LAW) on type II diabetes rats.

METHODS

Streptozotocin (65 mg/kg, i.p.) along with nicotinamide (120 mg/kg, i.p.) was used to induce non insulin dependent diabetes mellitus (NIDDM) in rats. A daily oral dose of aspirin (200 mg/kg, i.p.) was administered for initial seven days to induce gastric ulcerations in the diabetic rats. LAM and LAW were administered orally in the doses of 100, 200 and 400 mg/kg once daily for 21 days. Glibenclamide and ranitidine were used as standards for comparing the antidiabetic and antiulcer effect respectively.

RESULTS

LAM significantly (P<0.01) increased mucosal glycoprotein and antioxidant enzyme level in gastric mucosa of diabetic rats than LAW (P <0.05). LAM was efficient in reversing the delayed healing of gastric ulcer in diabetic rats close to the normal level. LAM exhibited better ulcer healing effect than glibenclamide and LAW, because of its both antihyperglycemic and mucosal defensive actions.

CONCLUSIONS

Thus, LAM is proved to be a better alternative for treating gastric ulcers co-occurring with diabetes.

摘要

目的

研究丝瓜甲醇提取物（LAM）和水提物（LAW）对 2 型糖尿病大鼠的比较胃保护作用。

方法

链脲佐菌素（65mg/kg，ip）联合烟酰胺（120mg/kg，ip）用于诱导非胰岛素依赖型糖尿病（NIDDM）大鼠。阿司匹林（200mg/kg，ip）每日口服一次，用于诱导糖尿病大鼠的胃溃疡。LAM 和 LAW 分别以 100、200 和 400mg/kg 的剂量每日口服一次，共 21 天。格列本脲和雷尼替丁分别用作比较抗糖尿病和抗溃疡作用的标准。