Franck J L, Bouteiller G, Gayrard M, Arlet J
Sem Hop. 1979;55(27-30):1325-7.
From literature data and their own experience, the authors comment hematological complications, related to the use of D-penicillamine, mainly in theumatoïd arthritis. Hypereosinophilia is more common than thrombopenia, but, both complications are usually benign. Anemia alone is very rare. Leukopenia appears in 6% of treated patients, but pancytopenia is rare. Leukopenia and pancytopenia are the most severe complications, even fatal in some cases. The safest dose of D-penicillamine seems to be between 600 and 900 mg per day, provided that, however, regular hematological controls may be achieved.
根据文献资料及自身经验，作者对与青霉胺使用相关的血液学并发症进行了评论，主要涉及类风湿性关节炎。嗜酸性粒细胞增多比血小板减少更常见，但这两种并发症通常都是良性的。单纯贫血非常罕见。白细胞减少出现在6%的接受治疗的患者中，但全血细胞减少很少见。白细胞减少和全血细胞减少是最严重的并发症，在某些情况下甚至会致命。青霉胺最安全的剂量似乎是每天600至900毫克，前提是要定期进行血液学检查。
