Fibroblast growth factor-2: an endogenous antidepressant and anxiolytic molecule?
作者信息
Turner Cortney A, Watson Stanley J, Akil Huda
机构信息
Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Biol Psychiatry. 2012 Aug 15;72(4):254-5. doi: 10.1016/j.biopsych.2012.05.025.
Abstract
摘要
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本文引用的文献
1
Antidepressant effects of fibroblast growth factor-2 in behavioral and cellular models of depression.成纤维细胞生长因子-2 在抑郁的行为和细胞模型中的抗抑郁作用。
Biol Psychiatry. 2012 Aug 15;72(4):258-65. doi: 10.1016/j.biopsych.2012.03.003. Epub 2012 Apr 17.
2
Fibroblast growth factor-2 (FGF2) augmentation early in life alters hippocampal development and rescues the anxiety phenotype in vulnerable animals.成纤维细胞生长因子-2（FGF2）在生命早期的增强作用改变了海马体的发育，并挽救了易感性动物的焦虑表型。
Proc Natl Acad Sci U S A. 2011 May 10;108(19):8021-5. doi: 10.1073/pnas.1103732108. Epub 2011 Apr 25.
3
Toward a novel endogenous anxiolytic factor, fibroblast growth factor 2.迈向一种新型内源性抗焦虑因子——成纤维细胞生长因子2 。
Biol Psychiatry. 2011 Mar 15;69(6):508-9. doi: 10.1016/j.biopsych.2011.01.017.
4
Short-hairpin RNA silencing of endogenous fibroblast growth factor 2 in rat hippocampus increases anxiety behavior.短发夹 RNA 沉默内源性成纤维细胞生长因子 2 可增加大鼠海马焦虑行为。
Biol Psychiatry. 2011 Mar 15;69(6):534-40. doi: 10.1016/j.biopsych.2010.11.020. Epub 2011 Jan 7.
5
A new role for FGF2 as an endogenous inhibitor of anxiety.成纤维细胞生长因子2作为内源性焦虑抑制剂的新作用。
J Neurosci. 2009 May 13;29(19):6379-87. doi: 10.1523/JNEUROSCI.4829-08.2009.
6
Antidepressant-like effects of intracerebroventricular FGF2 in rats.脑室内注射碱性成纤维细胞生长因子2对大鼠的抗抑郁样作用
Brain Res. 2008 Aug 11;1224:63-8. doi: 10.1016/j.brainres.2008.05.088. Epub 2008 Jun 14.
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Antidepressant treatments induce the expression of basic fibroblast growth factor in cortical and hippocampal neurons.抗抑郁治疗可诱导皮质和海马神经元中碱性成纤维细胞生长因子的表达。
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